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目的探讨微量垂体后叶素持续泵入联合奥曲肽治疗肝硬化合并食管胃底静脉曲张出血(EVB)的效果。方法选取入医院治疗的肝硬化和EVB患者78例作为研究对象,采用数字随机表将患者分为对照组和观察组,对照组予以奥曲肽,观察组在对照组基础上辅以微量垂体后叶素持续泵入,记录两组12h、24h止血率、肝功能恶化几率,记录平均止血时间、输血量,观察两组临床疗效及不良用药反应。结果观察组12h、24h止血率、肝功能恶化几率分别为76.92%、94.87%、10.26%均显著低于对照组,差异均具有统计学意义(P<0.05);观察组止血时间为(11.51±1.29)d较对照组短,输血量为(2.56±1.33)U较对照组少,差异具有统计学意义(P<0.05)。结论予以肝硬化合并EVB患者微量垂体后叶素持续泵入联合奥曲肽治疗,提高24h内止血率,减少输血量。
Objective To investigate the effect of continuous puerarin infusion combined with octreotide on cirrhosis combined with esophageal variceal hemorrhage (EVB). Methods Seventy-eight patients with cirrhosis and EVB selected from the hospital were enrolled in this study. The patients were divided into control group and observation group by digital randomized table, and octreotide was given to the control group. The observation group was supplemented with trace pituitrin Continuous pumping, recording two groups of 12h, 24h hemostasis rate, the possibility of deterioration of liver function, record the average hemostatic time, blood transfusion, observed two groups of clinical efficacy and adverse drug reactions. Results The rate of hemostasis and hepatic dysfunction in observation group at 12h and 24h were 76.92%, 94.87% and 10.26% respectively, which were significantly lower than those in control group (P <0.05). The bleeding time in observation group was (11.51 ± 1.29) d shorter than the control group, the blood transfusion (2.56 ± 1.33) U less than the control group, the difference was statistically significant (P <0.05). Conclusions Patients with cirrhosis complicated with EVB were given pituitrin pumped continuously with octreotide to improve the rate of hemostasis within 24h and reduce the volume of blood transfusion.