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树突状细胞(DCs)是功能强大的抗原递呈细胞,摄取抗原后,经淋巴管定向迁移进入淋巴结T细胞富集区,将抗原信息呈递给初始T细胞,从而引发一系列的特异性免疫应答。近年来发现DCs在体内该阶段迁移过程有一系列细胞因子和信号传导通路参与调控,其中CCR7及其配体CCL19和CCL21是最受关注的一组趋化因子。随着对调控机制研究的不断深入,发现MAPK信号途径和NFκB途径也参与迁移调控,另有一些因素则对其产生负调节作用。掌握调控DCs迁入淋巴组织的机制,有助于体外培养DCs为基础的过继性抗肿瘤免疫治疗技术的发展。
Dendritic cells (DCs) are potent antigen-presenting cells. After the antigen is taken up, they migrate through the lymphatic vessels into the T cell-rich region of the lymph node and present the antigen information to the naive T cells, triggering a series of specific immunizations answer. In recent years, DCs have been found to have a series of cytokines and signal transduction pathways involved in the process of migration in this stage. Among them, CCR7 and its ligands CCL19 and CCL21 are the most concerned group of chemokines. With the deepening of research on regulatory mechanisms, MAPK signaling pathway and NFκB pathway are also found to be involved in migration regulation, while other factors have a negative regulatory effect. To master the mechanism of DCs immigration into lymphoid tissues and contribute to the development of DCs-based adoptive antitumor immunotherapy technology.