论文部分内容阅读
目的:分析儿童严重药品不良反应/事件(ADR/ADE)发生的相关因素,以减少其发生率及危害程度。方法:以2010年1月至2014年6月广西省百色市药品不良反应监测中心收集的187例儿童严重ADR/ADE报告为对象,采用回顾性研究方法进行统计分析。结果:本组资料中,0~3岁患儿比例最高(43.32%);静脉给药是引发严重ADR/ADE的主要给药途径(86.64%);抗菌药物引发的严重ADR/ADE最多(41.71%),其次为中药注射剂(23.00%);儿童严重ADR/ADE可能与不合理用药相关;非儿童专用药品可能更易导致严重ADR/ADE的发生。结论:应针对性地加强儿童严重ADR/ADE监测工作,避免或减少严重ADR/ADE给儿童造成的伤害。
Objective: To analyze the related factors of ADR / ADE in children so as to reduce their incidence and harm. METHODS: A total of 187 children with severe ADR / ADE collected from January 2010 to June 2014 in the Baise Municipality Center for Drug Adverse Reaction Monitoring at Guangxi Zhuang Autonomous Region were enrolled in this study. The data were analyzed retrospectively. Results: In this study, the highest proportion of children aged 0-3 years (43.32%) was given intravenously; the main route of administration (86.64%) was intravenous drug-induced ADR / ADE; the most serious ADR / ADE %), Followed by traditional Chinese medicine injection (23.00%). Serious ADR / ADE in children may be related to irrational drug use. Non-children-specific drugs may lead to serious ADR / ADE. Conclusion: The monitoring of ADR / ADE in children should be strengthened in a targeted manner to avoid or reduce the harm to children caused by severe ADR / ADE.