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目的探讨黄疸婴幼儿检测巨细胞病毒的临床意义。方法将74例黄疸婴幼患儿分为两组,其中阳性组为34例CMV阳性患儿;对照组为40例CMV阴性患儿。采用酶联免疫吸附实验(ELISA)法,检测血清CMV-IgM;用FQ-PCR法检测尿CMV-DNA;血清肝功能检查。对两组肝功能测定结果比较分析。结果 CMV阳性组和对照组的丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总胆红素(TB)、直接胆红素(DB)、总胆汁酸(TBA),检测结果均有统计学意义(P<0.01)。阳性组ALT、AST、ALP、TBA检测结果明显高于对照组。结论婴幼儿黄疸,CMV感染不容忽视,肝功能受损,治疗困难,重在预防。母婴传播是小儿CMV感染的主要途径,育龄妇女在怀孕前做CMV检查,对优生优育,有重要作用。
Objective To investigate the clinical significance of detection of cytomegalovirus in infants with jaundice. Methods 74 cases of infants with jaundice were divided into two groups, of which 34 cases were CMV positive in the positive group and 40 cases were negative in the control group. Serum CMV-IgM was detected by enzyme-linked immunosorbent assay (ELISA); urine CMV-DNA was detected by FQ-PCR; serum liver function was examined. Comparison of the results of two groups of liver function tests. Results The positive rates of ALT, AST, ALP, TB and Bilirubin in CMV positive group and control group DB), total bile acid (TBA), the test results were statistically significant (P <0.01). The results of ALT, AST, ALP and TBA in the positive group were significantly higher than those in the control group. Conclusion Infants jaundice, CMV infection can not be ignored, impaired liver function, treatment difficulties, focusing on prevention. Mother-to-child transmission is the main route of CMV infection in infants. Women of childbearing age have CMV examination before pregnancy, which plays an important role in prenatal and postnatal care.