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目的探讨恶性胸液中葡萄糖转运蛋白-1(GLUT-1)和诱导型一氧化氮合成酶(iNOS)的表达水平及临床意义。方法检测70例胸腔积液患者(良性积液30例、恶性积液40例)血清和胸液中GLUT-1和iNOS的表达水平,并将检测结果进行对比。结果恶性组胸液中GLUT-1和iNOS水平显著高于良性组水平(P<0.01),血清中GLUT-1和iNOS水平略高于良性组,但无统计学意义(P>0.05),两组患者胸液中的GLUT-1和iNOS水平均高于同组血清中的水平。结论 GLUT-1和iNOS在恶性胸液中高表达,临床上检测二者的水平可能有助于恶性胸腔积液的诊断。
Objective To investigate the expression of glucose transporter 1 (GLUT-1) and inducible nitric oxide synthase (iNOS) in malignant pleural effusion and its clinical significance. Methods The expression of GLUT-1 and iNOS in serum and pleural effusion of 70 patients with pleural effusion (30 cases of benign effusion and 40 cases of malignant effusion) was detected by ELISA. The results were compared. Results The levels of GLUT-1 and iNOS in malignant group were significantly higher than those in benign group (P <0.01). The levels of GLUT-1 and iNOS in serum were slightly higher than those in benign group, but there was no significant difference (P> 0.05) The levels of GLUT-1 and iNOS in the pleural fluid of the patients were higher than those in the same group. Conclusions GLUT-1 and iNOS are highly expressed in malignant pleural effusions. The detection of both of them may contribute to the diagnosis of malignant pleural effusions.