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目的探讨幽门螺杆菌(Hp)感染及非甾体类抗炎药(NSAID)相关胃溃疡中基质金属蛋白酶7(MMP-7)、9(MMP-9)、基质金属蛋白酶组织抑制剂1(TIMP-1)的表达及意义,分析MMP-7、MMP-9、TIMP-1等指标在Hp感染及NSAID相关性胃溃疡中的可能作用。方法选择2014年胃溃疡患者90例为研究对象,其中36例为Hp感染(Ⅰ组)、32例口服NSAID药物患者(Ⅱ组)、22例同时伴有Hp感染及NSAID药物双重作用所致(Ⅲ组),另选择同期在医院体检的50名健康者为对照组,检测血清MMP-7、MMP-9及TIMP-1水平,利用SPSS17软件对数据进行统计分析。结果溃疡组血清MMP-7、MMP-9、TIMP-1水平高于对照组,差异有统计学意义(P<0.01),Ⅰ组血清MMP-7、MMP-9、TIMP-1水平高于Ⅱ组和Ⅲ组,差异有统计学意义(P<0.01),Ⅱ组和Ⅲ组血清MMP-7、MMP-9、TIMP-1水平差异无统计学意义。结论胃溃疡患者血清中MMP-7、MMP-9、TIMP-1表达增高,并且MMP-7、MMP-9、TIMP-1的表达与Hp感染及使用NSAID密切相关。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and non-steroidal anti-inflammatory drugs (NSAID) -associated gastric ulcer in patients with gastric ulcer and their relationship with the expression of matrix metalloproteinase 7 (MMP-9), matrix metalloproteinase inhibitor 1 -1), and to analyze the possible role of MMP-7, MMP-9 and TIMP-1 in Hp infection and NSAID-related gastric ulcer. Methods Ninety patients with gastric ulcer in 2014 were enrolled. Among them, 36 were Hp infection (group Ⅰ), 32 patients were treated with NSAID (group Ⅱ), 22 were complicated by Hp infection and NSAID drug ( Group Ⅲ). The other 50 healthy subjects in the same period were selected as the control group. The levels of serum MMP-7, MMP-9 and TIMP-1 were detected and the data were analyzed by SPSS17 software. Results The levels of serum MMP-7, MMP-9 and TIMP-1 in ulcer group were significantly higher than those in control group (P <0.01). The serum levels of MMP-7, MMP-9 and TIMP- (P <0.01). The serum levels of MMP-7, MMP-9 and TIMP-1 in group Ⅱ and group Ⅲ had no statistical significance. Conclusions The serum levels of MMP-7, MMP-9 and TIMP-1 in patients with gastric ulcer are increased, and the expressions of MMP-7, MMP-9 and TIMP-1 are closely related to Hp infection and the use of NSAID.