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我们用放射免疫分析方法检测了肝硬化患者尿中3种微量蛋白,同时测定了血清部分免疫球蛋白和补体。结果,43例肝硬化一般肾功能正常患者尿白蛋白明显增高者29例(67％),尿IgG增高者24例(55％),THP增高者18例(42％),与正常对照组比差异具显著性。血清IgA显著升高,且与尿白蛋白增高相平行,但不同肝功能分级间无明显变化。因此,我们认为血清IgA升高与肝硬化肾病形成有关,尿微量蛋白测定可作为肝硬化亚临床肾病的诊断方法。
We used radioimmunoassay to detect urinary microalbumin in cirrhotic patients and determined serum immunoglobulin and complement at the same time. Results: Of the 43 patients with cirrhosis and normal renal function, the urinary albumin was significantly higher in 29 patients (67%), the urine IgG increased in 24 patients (55%) and the higher THP in 18 patients (42%). Compared with the normal control group The difference is significant. Serum IgA increased significantly, and parallel with increased urinary albumin, but no significant difference between different liver function grading. Therefore, we think that elevated serum IgA is associated with the formation of cirrhosis and nephrotoxicity, and microalbuminuria may be used as a diagnostic method for subclinical cirrhosis of liver cirrhosis.