论文部分内容阅读
目的:探讨血清前S1蛋白在乙型肝炎病毒(HBV)感染中的临床意义。方法:采用ELISA法对278例乙型肝炎患者前S1蛋白,乙肝血清标志物进行检测。同时进行HBV-DNA测定,并取60份体检正常者血清作为正常对照。结果:HBV高复制组(HBeAg、HBV-DNA、HBcAb阳性各组)中血清前S1蛋白阳性率高,低复制组阳性率较低。结论:血清HBV前S1蛋白是反映HBV复制状态、传染性和预后的良好指标之一。
Objective: To investigate the clinical significance of pre-S1 protein in hepatitis B virus (HBV) infection. Methods: Serum pre-S1 protein and HBV markers of 278 hepatitis B patients were detected by ELISA. At the same time, HBV-DNA was measured, and 60 healthy subjects were taken as normal control. Results: The positive rate of serum pre-S1 protein in HBV high replication group (HBeAg, HBV-DNA and HBcAb positive groups) was high, and the positive rate in low replication group was low. Conclusion: Serum HBV pre-S1 protein is one of the good indicators reflecting HBV replication status, infectivity and prognosis.