目的:研究氟比洛芬口服给药的药物动力学及生物利用度。方法:利用HPLC法测定氟比洛芬的血药浓度,以交叉给药方式分别给予家兔注射剂和口服混悬剂并且对其药物动力学和生物利用度进行研究。结果:氟比洛芬在家兔体内药动学静脉注射符合二室开放模型,口服符合一室开放模型,氟比洛芬口服混悬剂的绝对生物利用度为61.9%。结论:在进行氟比洛芬剂型研究时应注重提高其口服制剂的生物利用度。 OBJECTIVE: To study the pharmacokinetics and bioavailability of flurbiprofen administered orally. Methods: The plasma concentration of flurbiprofen was determined by HPLC. Rabbits were injected with oral solution and oral suspension by crossover method. The pharmacokinetics and bioavailability were also studied. Results: Flurbiprofen intravenously in rabbits pharmacokinetic intravenous injection in line with the two-compartment open model, oral compliance with one-compartment open model, the absolute bioavailability of flurbiprofen oral suspension was 61.9%. CONCLUSION: In the study of flurbiprofen dosage forms, the bioavailability of oral formulations should be increased.