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目的:探讨血清Ⅰ型胶原吡啶交联终肽(ICTP)在类风湿关节炎(RA)中的临床意义。方法:对入选的86例RA患者、41例非RA患者及正常对照40例,采用酶联免疫吸附试验(ELISA)检测ICTP。结果:血清ICTP在RA组、非RA组中的浓度与正常对照组比较,均有显著性差异(P<0.05);与非RA组比较,RA组血清ICTP含量及阳性率均有统计学意义(均P<0.05)。结论:ICTP可作为RA患者关节损伤指标,对判断病情活动有重要意义。
Objective: To investigate the clinical significance of serum type Ⅰ collagen pyridine cross-linked terminal peptide (ICTP) in rheumatoid arthritis (RA). Methods: Totally 86 patients with RA, 41 non-RA patients and 40 normal controls were enrolled in this study. ICTP was detected by enzyme linked immunosorbent assay (ELISA). Results: Compared with the normal control group, the serum concentration of ICTP in RA group and non-RA group were significantly different (P <0.05). Compared with non-RA group, the serum ICTP level and the positive rate in RA group were statistically significant (All P <0.05). Conclusion: ICTP can be used as a marker of joint injury in patients with RA, which is of great significance in judging the disease activity.