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系统性红斑狼疮是涉及所有器官的高度异质性疾病。对于系统性红斑狼疮的流行率，病理机制和其生物标志物的研究是系统性红斑狼疮研究的3个重要方面。系统性红斑狼疮的流行性在不同的地区存在差异，这些差异的存在是由很多方面因素引起，目前普遍公认的影响因素主要有遗传，人种和生活环境等。系统性红斑狼疮的病理机制研究对该病的治疗具有最为关键的作用，但也是最难攻克的课题，至今的研究还未取得突破性的进展，许多问题还未解决。而生物标志物对于研究系统性红斑狼疮的流行率和病理机制的研究具有重要的意义，同时生物标志物对于系统性红斑狼疮的预防和治疗等方面有极大的帮助。“,”Systemic lupus erythematosus( SLE) is a highly heterogeneous disease involving all organs. The prevalence,pathogenesis,and biological markers are three important aspects for the study of SLE .Preva-lence of SLE in different areas is different caused by many factors,among which genetic factors,race and liv-ing environment are widely recognized.The pathogenesis study of SLE is the key for the treatment of the dis-ease,but it′s also the most difficult to conquer.Research has not made breakthrough progress yet,many prob-lems still unresolved.Biomarkers are of great importance to study the prevalence and pathogenesis of SLE, and may contribute to the prevention and treatment.