一位43岁的妇女因深部静脉血栓形成,用华法令作抗凝治疗。在头3天用药总量达25 mg 后,改为每天5 mg。凝血酶原时间维持在19 s。7周后每天加用他莫昔芬40 mg,次日凝血酶原时间达38 s,将华法林减为1mg/d,凝血酶原时间稳定在20～25 s。作者对18名乳腺癌后因严重血栓栓塞而住院的妇 A 43-year-old woman is treated with warfarin for anticoagulation due to deep venous thrombosis. In the first three days after the total dose of 25 mg, to 5 mg per day. Prothrombin time was maintained at 19 s. After 7 weeks, tamoxifen was added 40 mg daily, the prothrombin time of the next day was 38 s, the warfarin level was reduced to 1 mg / d, and the prothrombin time was stable at 20-25 s. The author of 18 patients with breast cancer hospitalized for severe thromboembolism