[目的]测评降糖颗粒急性毒性实验的最大耐受量,为临床应用提供安全性报告。[方法]观察小鼠24 h内在给予大剂量降糖颗粒治疗后所产生的急性毒性反应。[结果]小鼠经口服大剂量降糖颗粒其最大耐受量>180g生药/kg,无毒性反应。[结论]临床给予降糖颗粒是安全的。 [Objective] To evaluate the maximum tolerability of Jiangtang granules in acute toxicity experiment and provide safety report for clinical application. [Method] The acute toxicity reaction of mice treated with high-dose Jiangtang granules within 24 hours was observed. [Result] Mice were orally administered with high-dose hypoglycemic agents and the maximum tolerated dose was> 180g crude drug / kg, with no toxic reaction. [Conclusion] The clinical administration of hypoglycemic granules is safe.