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目的：进一步了解ＩＬ１β、ＩＬ６在慢性乙型肝炎发病过程中的作用。方法：本文采用斑点杂交方法对２０例慢性乙型肝炎患者和１０例健康人外周血单个核细胞中ＩＬ１β、ＩＬ６ｍＲＮＡ的表达水平进行了检测，同时运用ＡＢＣ免疫组化法对１３例慢性乙型肝炎患者肝组织及８例非肝病患者肝组织中ＩＬ１β、ＩＬ６的表达水平进行了检测。结果：慢性乙型肝炎患者外周血和肝组织中ＩＬ１β、ＩＬ６的表达水平均升高。结论：慢性乙型肝炎患者外周血及肝组织中ＩＬ１β、ＩＬ６的水平的升高可能发生在基因转录水平上，其与慢性乙型肝炎患者病变的发展和肝硬化的形成有着十分密切的关系。
Objective: To further understand the IL 1β, IL 6 in the pathogenesis of chronic hepatitis B role. Methods: Dot blot hybridization method was used to detect the expression levels of IL1β and IL6 mRNA in peripheral blood mononuclear cells from 20 patients with chronic hepatitis B and 10 healthy people. At the same time, ABC immunohistochemical method was used to detect 13 cases Chronic hepatitis B patients with liver tissue and 8 cases of non-liver disease in liver tissue IL 1β, IL 6 expression levels were detected. Results: The levels of IL1β and IL6 in peripheral blood and liver tissue of patients with chronic hepatitis B were increased. Conclusion: The levels of IL1β and IL6 in peripheral blood and liver tissues of patients with chronic hepatitis B may occur at the level of gene transcription, which is closely related to the development of pathological changes and the formation of liver cirrhosis in patients with chronic hepatitis B close relationship.