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本文对45例原发性高血压按用药前基础血浆肾素活性(PRA)分为高、正、低三组,分别测用药前及服硝苯啶二周后的血清和尿钙、镁、钠及全血离子钙和血压。结果发现:低肾素型原发性高血压全血离子钙、血清镁以及尿钙、镁比正常血压组明显升高(比高、正肾素型原高更明显)。经服硝苯啶二周,低肾素型原发性高血压患者血压及血镁、尿钙、镁、钠均趋向正常水平,提示不同肾素分型的原发性高血压服硝苯啶前、后其钙、镁、钠代谢存在异质性。
In this paper, 45 cases of essential hypertension according to the pre-medication basal plasma renin activity (PRA) is divided into high, positive and low three groups were measured before and after taking nifedipine serum and urinary calcium, magnesium, Sodium and whole blood ionized calcium and blood pressure. The results showed that the content of ionized calcium, serum magnesium, urinary calcium and magnesium in whole blood of patients with low renin type hypertension were significantly higher than that of the normal blood pressure group (more obvious than that of the high and positive Renin type). After taking nifedipine for two weeks, the blood pressure and serum magnesium, urinary calcium, magnesium and sodium of the patients with low renin type essential hypertension were all in the normal level, suggesting that the different types of essential hypertension with different renin subtype were treated with nifedipine Before and after its calcium, magnesium, sodium metabolism heterogeneity.