大骨节病(Kashin-Beck Disease,KBD)是一种慢性、地方性、变形性骨关节病,致残率很高,严重危害人民健康。KBD病因历经了160余年研究,先后提出多种学说,国家“八五”KBD科技攻关项目研究表明,迄今没有一种学说能与该病建立较完备的因果关系,几种病因学说都未得到证实。因此,目前KBD的病因不清,发病机制需要阐明,至今缺乏针对病因的一级防治措施。为此,我们以儿童KBD患者作为研究对象,应 Kashin-Beck Disease (KBD) is a chronic, endemic, and degenerative osteoarthropathy that has a high rate of disability and seriously endangers people’s health. KBD etiology after more than 160 years of research, has put forward a variety of doctrines, the national “eight five ” KBD research project shows that so far there is no doctrine to establish a more complete causal relationship with the disease, several theories of etiology have not Confirmed. Therefore, the current etiology of KBD is unclear, and the pathogenesis needs to be elucidated. To date, there is a lack of primary prevention and control measures for etiology. To this end, we take children KBD patients as the research object, should