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目的 :探讨芳香烃溶剂暴露和母亲细胞色素P45 0氧化酶 (MSP1) ,谷胱甘肽S转移酶Theta(GSTT1)和谷胱甘肽S转移酶M 1(GSTM1)的基因多态性对新生儿出生身长的影响。方法 :采用回顾性流行病学调查方法 ,使用统一调查表 ,由经过培训的调查员在北京燕山地区调查了 6 44个母亲婴儿对。结果 :(1)单因素分析发现 :GSTM1缺失基因型可致新生儿出生身长显著降低 ,但未观察到基因GSTT1、MSP1及芳香烃溶剂暴露对新生儿出生身长的影响。 (2 )采用多元线性回归模型 ,经母亲文化程度、年龄、被动吸烟、倒班、生育史、孕前身高、孕前体重、父亲身高、体重、婴儿性别、孕周、出生体重调整后 ,可见基因GSTM1、GSTT1及芳香烃溶剂暴露均能显著致新生儿出生身长降低。 (3)我们将芳香烃溶剂 (暴露与非暴露 ) ,母亲基因MSP1(野生型、杂合子 /突变型 )与基因GSTM1(存在型 ,缺失型 )分为 8组 ,在芳香烃溶剂暴露组 ,可见母亲基因型致出生身长呈斜线降低 ,然而在芳香烃溶剂非暴露组 ,其母亲基因型对出生身长的影响无明显改变。在芳香烃溶剂 (暴露与非暴露 ) ,MSP1杂合子 /突变基因型合并GSTT1缺失基因型组 ,我们得到了类似的结果。结论 :基因MSPI ,GSTT1,GSTM 1与芳香烃溶剂暴露之间对新生儿出生身长的影响可能存在交互作用 ,这为基因
OBJECTIVE: To investigate the effects of aromatic hydrocarbon solvent exposure and genetic polymorphisms of maternal cytochrome P45 0 oxidase (MSP1), glutathione S transferase Theta (GSTT1) and glutathione S transferase M 1 (GSTM1) The impact of the child’s birth length. METHODS: Using a retrospective epidemiological survey methodology, a single questionnaire was used by trained investigators to investigate 6 44 maternal infant pairs in the Yanshan area of Beijing. Results: (1) Univariate analysis showed that the genotype of GSTM1 deletion significantly decreased the neonatal birth size, but no effects of GSTT1, MSP1 and aromatic solvent exposure on newborn birth length were observed. (2) Using multivariate linear regression model, the gene GSTM1, GSTM1, GSTM1, GSTM1 and GSTM1 were observed after adjustment of maternal education, age, passive smoking, GSTT1 and aromatic hydrocarbon solvent exposure can significantly reduce the length of newborn babies born. (3) We divided aromatic solvent (exposed and non-exposed), maternal gene MSP1 (wild type, heterozygote / mutant) and gene GSTM1 (existent and deletion type) into 8 groups, However, in the non-exposed group of aromatic hydrocarbon solvent, the effect of the mother’s genotype on the length of the newborn had no significant change. We obtained similar results with the MSP1 heterozygote / mutant genotype combined with the GSTT1 null genotype in aromatic solvents (exposed and non-exposed). CONCLUSIONS: There may be an interaction between the effects of MSPI, GSTT1, GSTM1 and aromatic solvent exposure on newborn birth length, which is a gene