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目的探讨5,10-亚甲基四氢叶酸还原酶(MTHFR)C667T位点基因多态性与结直肠癌发生的关系。方法检索中外文数据库,收集有关MTHFR基因C677T多态性与结直肠癌相关性的病例对照研究,采用TT/CC以及TT/CC+CT基因型比较模型进行定量综合分析,然后按种族、位置和性别分亚组进行分析。结果综合分析显示,MTH-FR基因677位点TT/CC、TT/CC+CT模型计算OR值95%CI分别为0.93(0.84~1.03)、0.92(0.84~1.01);按位置分层,突变基因型与结肠癌易感性有关TT/CC+CTOR值(95%CI)为0.88(0.79~0.98),而与直肠癌无关;按性别分层,在男性中突变基因型与结直肠癌易感性有关TT/CC、TT/CC+CT模型OR值(95%CI)分别为0.82(0.70-0.96)、0.82(0.71~0.96),而与女性无关;在种族分层中,没有发现突变基因型与结直肠癌发病有关。结论 MTHFRC667T位点突变基因型与女性结直肠癌易感性无关,但可能降低男性结直肠癌的发病风险,TT基因型与CC+CT基因型相比是结肠癌发病风险的保护因素。
Objective To investigate the relationship between the gene polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) C667T and the occurrence of colorectal cancer. Methods Chinese and foreign language databases were searched and the case-control study on the relationship between MTHFR gene C677T polymorphism and colorectal cancer was collected. The TT / CC and TT / CC + CT genotype comparison models were used for quantitative and comprehensive analysis, and then by ethnicity, location and Gender sub-group for analysis. Results The results of comprehensive analysis showed that the 95% CIs for OR of MTH-FR gene 677 TT / CC and TT / CC + CT models were 0.93 (0.84-1.03) and 0.92 (0.84-1.01), respectively; The TT / CC + CTOR values (95% CI) for genotype and colon cancer susceptibility were 0.88 (0.79-0.98), but not for rectal cancer; the genotype was associated with susceptibility to colorectal cancer in men by sex The OR (95% CI) of TT / CC and TT / CC + CT models were 0.82 (0.70-0.96) and 0.82 (0.71-0.96), respectively, but not in females. No mutation genotypes were found in racial stratification And the incidence of colorectal cancer. Conclusion The MTHFRC667T locus mutation genotype is not related to the susceptibility of female patients with colorectal cancer, but may reduce the risk of developing colorectal cancer. Compared with CC + CT genotype, TT genotype is the protective factor of the risk of colon cancer.