目的　研究胸部肿瘤患者手术前后STNFRI在血清中的变化。方法　采用ELISA方法测定了 46例食管癌 ,32例贲门癌 ,80例肺癌 ,1 4例非肿瘤患者 ,61例志愿健康成年人。结果　胸部肿瘤患者中可溶性肿瘤坏死因子 (STNFRI)的平均水平明显高于健康对照组和非肿瘤组。按肿瘤的TNM分期 ,STNFRI手术前后的值和升高幅度与疾病分期明显相关 ,与病理类型无关 (P <0 .0 1 )。结论　在排除自身免疫疾病和感染 ,STNFRI的测定对肿瘤的诊断 ,筛选 ,预后有辅助意义。 Objective To study the changes of serum STNFRI in patients with thoracic tumor before and after surgery. Methods ELISA was used to detect 46 cases of esophageal cancer, 32 cases of cardiac cancer, 80 cases of lung cancer, 14 cases of non-tumor patients, 61 cases of volunteer healthy adults. Results The average level of soluble tumor necrosis factor (STNFRI) in patients with thoracic tumors was significantly higher than that in healthy controls and non-tumor patients. According to the TNM stage of the tumor, the value of the STNFRI before and after surgery was significantly related to the stage of disease, but not to the pathological type (P < 0.01). Conclusions In the exclusion of autoimmune diseases and infections, the determination of STNFRI is useful for the diagnosis, screening, and prognosis of tumors.