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目的比较1段和6段法设定胰岛素泵基础率对T2DM患者疗效的影响。方法观察我院149例应用胰岛素泵治疗的T2DM患者,据治疗方案分为1段基础率组(A组,n=74)和6段基础率组(B组,n=75),比较两组血糖达标时间、胰岛素用量、血糖控制情况及低血糖发生率。结果两组达标时间差异无统计学意义;B组每日胰岛素总量[(38.2±9.26)vs(41.9±9.67)U/d,P<0.05]及餐前量[(20.7±6.56)vs(23.15±6.12)U/d,P<0.05]低于A组,两组基础量差异无统计学意义;达标时,两组5个时点血糖水平差异均无统计学意义,但B组一日内血糖水平标准差[(2.23±0.83)vs(2.72±1.09),P<0.05]低于A组;B组低血糖发生率也低于A组。结论 6段法设定胰岛素泵基础率可减少每日胰岛素用量,特别是餐前量,降低血糖波动,减少低血糖发生,更平稳地改善T2DM患者的血糖控制。
Objective To compare the effects of primary and secondary insulin pump rates on T2DM patients. Methods A total of 149 patients with T2DM treated with insulin pump were enrolled in this study. According to the treatment plan, they were divided into two groups according to the treatment regimen: basal rate group (A group, n = 74) and basal rate group (B group, n = 75) Blood glucose compliance time, insulin dosage, glycemic control and hypoglycemia. Results There was no significant difference in the standard time between the two groups. The daily total amount of insulin in group B [(38.2 ± 9.26) vs (41.9 ± 9.67) U / d, P <0.05] 23.15 ± 6.12) U / d, P <0.05], but there was no significant difference in basal amount between the two groups. There was no significant difference in blood glucose level between the two groups The standard deviation of blood glucose level was (2.23 ± 0.83) vs (2.72 ± 1.09), P <0.05], lower than that in group A, and the incidence of hypoglycemia in group B was also lower than that in group A Conclusion The 6-segment method set the basal rate of insulin pump can reduce the amount of daily insulin, especially the amount of pre-meal, lower blood sugar fluctuations, reduce the incidence of hypoglycemia, smoother improvement of glycemic control T2DM patients.