六盘水市水城地区于1988年发生伤寒流行以来，一直流行不断。本文就1988年3月至1992年11月间收治的948例伤寒作了临床分析，结果显示这批伤寒具有病情重、并发症多、病死率高、多重耐药治疗困难等特点。这与近年来认为伤寒临床变迁不典型化、轻型化有很大不同，故认为有必要加以重新认识。另外，对耐药伤寒的诊治也谈了自己的体会。 Since the epidemic of typhoid fever in 1988, the water city in Liupanshui City has been in constant epidemic. The clinical analysis of 948 cases of typhoid fever treated between March 1988 and November 1992 showed that these typhoid fever were characterized by severe illness, multiple complications, high mortality and difficulty of multidrug resistance. This is in recent years that the clinical changes in typhoid atypical, light-weight are very different, so it is necessary to be re-recognized. In addition, the diagnosis and treatment of resistant typhoid also talked about their own experience.