论文部分内容阅读
对新型消毒剂碘附Ⅰ号进行了急性毒性(包括经口 LD_(50)、经皮 LD_(50)和粘膜及皮肤的刺激试验)和致敏作用的研究。结果表明:大、小鼠 LD_(50)说明该碘附Ⅰ号属于低毒物质,豚鼠经皮 LD_(50)未能测出。粘膜刺激试验:碘附Ⅰ号原液对眼粘膜有强刺激作用;50%碘附Ⅰ号液有中等刺激作用;25%、5%、2%及1%的碘附Ⅰ号液无任何刺激作用。家兔皮肤刺激试验显示无皮肤刺激作用。豚鼠皮肤致敏试验结果无致敏作用。因此,我们认为碘附Ⅰ号液是一种有前途的皮肤及医疗器械消毒剂。
Acute toxicity (including oral LD_ (50), transdermal LD_ (50) and mucous membrane and skin irritation test) and sensitization effect of the new disinfectant Iodine Ⅰ were studied. The results showed that LD_ (50) of large and small mice showed that the iodine attached Ⅰ was a low toxic substance, and the guinea pig percutaneous LD_ (50) could not be detected. Mucosal irritation test: Iodine on the 1st lotion has a strong irritant effect on the ocular mucosa; 50% Iodine on the 1st liquid has a moderate stimulus; 25%, 5%, 2% and 1% iodine on the 1st liquid without any stimulus . Rabbit skin irritation test showed no skin irritation. Guinea pig skin sensitization test results no sensitization. Therefore, we believe that iodine solution No. 1 is a promising skin and medical device disinfectant.