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哮喘发作的主要原因有三:气道平滑肌痉挛、粘膜水肿和粘液分泌过多。由于气道中β肾上腺素受体(简称β受体)所介导的反应,最终能导致平滑肌舒张、抑制组胺等过敏介质释放以及增强纤毛运动等效应,在维持气道正常生理功能中起着举足轻重的作用,因此,在研究哮喘的发病机理乃至寻求有效防治措施时,倍受重视。本研究采用放射性配基结合分析,结合相应神经递质和环核苷酸含量测定,在对正常豚鼠肺组织中肾上腺素受体检定的基础上,观察和分析了实验性过敏性哮喘时肾上腺素受体的变化,对它们在哮喘病的发病中的意义作了初步探讨。
There are three main causes of asthma attacks: airway smooth muscle spasms, mucosal edema, and mucus hypersecretion. Due to the beta-adrenergic receptor (beta receptor) -mediated responses in the airways, it eventually leads to relaxation of the smooth muscle, inhibition of the release of histamine and other allergic mediators and enhancement of ciliary motility and other effects, plays a role in maintaining normal physiological function of the airway Play a decisive role in the study of the pathogenesis of asthma and even seek effective prevention and control measures, much attention. In this study, radioligand binding analysis, combined with the corresponding neurotransmitter and cyclic nucleotide content determination, based on the normal guinea pig lung tissue adrenaline receptor assay, based on the observation and analysis of experimental allergic asthma epinephrine Receptor changes, their significance in the pathogenesis of asthma made a preliminary study.