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由于传统的新药研究需耗费大量经费及时间,目前重点是开发新的给药体系,使临床有效的药物能发挥最好的疗效。透皮控释给药体系即为其中较易生产及耗资较少的一类。透皮控释给药的优点如下:1.可绕过肝脏的首过效应及胃肠道干扰;2.可缩小病人个体间及个体内(各次服药间)的差异;3.较易维持稳定的血药浓度;4.能延长药物作用时间;5.能提高药物治疗效果;6.可减少给药频率;7.使用方便,使病人乐于应用。治疗指数低的药物用传统剂型给药难以控制血药浓度,使用不安全。半衰期短的药物需频繁给药,很不方便。这些药物均可以
As the traditional new drug research requires a large amount of funding and time, the current focus is to develop new drug delivery systems so that clinically effective drugs can exert the best therapeutic effect. Transdermal controlled release drug delivery system is one of the easier to produce and less expensive. The advantages of transdermal controlled-release administration are as follows: 1. The first-pass effect of bypassing the liver and gastrointestinal disturbances can be achieved; 2. the difference between patients and individuals can be reduced; 3. the more easily maintained Stable blood concentration; 4. can extend the duration of drug effects; 5. can improve the therapeutic effect of drugs; 6. can reduce the frequency of administration; 7. easy to use, so that patients are happy to use. Low therapeutic index drugs with traditional dosage form difficult to control blood concentration, the use of unsafe. Short half-life of drugs to be frequently administered, very inconvenient. These drugs are ok