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60 Coγ射线照射能引起人红白血病K5 6 2细胞株的血型糖蛋白A基因发生随机突变。通过对其第 3外显子上的SacI内切酶位点进行分析 ,发现其基因突变率与受照剂量有着较好的线性关系 ,这与染色体畸变分析法所得的结果一致。分析基因突变率有可能推知受照剂量
60 Co γ-ray irradiation can cause random mutation of the blood glycoprotein A gene in human erythroleukemia K5 6 2 cell line. By analyzing the SacI endonuclease site on the third exon, we found that there was a good linear relationship between the gene mutation rate and the irradiated dose, which is consistent with the result obtained by chromosomal aberration analysis. Analysis of gene mutation rate may infer the exposure dose