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作者应用免疫组化法对102例人原发性肝细胞癌(PHC)组织进行了HCV及HBV抗原定位研究。HCVC33c抗原及HBxAg在PHC中的阳性检出率分别是81.4%及74.5%,C33c抗原和HBxAg阳性占所检病例94.1%,二者同时阳性为61.8%,102例PHC中50例有癌旁肝组织,其C33c抗原和HBxAg的阳性检出率分别是62%和92%。HCVC33c抗原定位于肝癌细胞的胞浆内,在胞浆内局灶分布或充满整个胞浆,有的紧靠核膜,胞核未见阳性信号。C33c抗原阳性细胞在PHC中呈散在、局灶分布为主,在癌旁肝组织呈弥漫分布为主。
The authors used immunohistochemistry to study the localization of HCV and HBV antigens in 102 human primary hepatocellular carcinoma (PHC) tissues. The positive detection rates of HCVC33c antigen and HBxAg in PHC were 81.4% and 74.5%, respectively. C33c antigen and HBxAg positive accounted for 94.1% of the detected cases. Both positive and positive were 61.8% and 102 cases respectively. 50 cases of PHC had paraneoplastic liver tissue, and the positive detection rates of C33c antigen and HBxAg were 62% and 92%, respectively. The HCVC33c antigen was localized in the cytoplasm of hepatocellular carcinoma cells, local distribution in the cytoplasm or full cytoplasm, and some close to the nuclear membrane, no positive signal in the nucleus. The C33c antigen-positive cells were scattered and localized mainly in PHC, and diffusely distributed in the adjacent liver tissue.