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用高度抗氯喹约氏疟原虫 Ac—1虫株感染小鼠观察了酮替芬及赛庚啶对氯喹抗药性的逆转作用,1/4治疗剂量的酮替芬及赛庚啶己可使抗氯喹特性被逆转,使抗性虫感染小鼠被敏感株治疗剂量所治愈。提高剂量杀虫作用加强。异博定相应的效果较差且毒性较高。预先或同时加服蛋白质合成抑制剂氯霉素或利福平则未观察到对氯喹抗药性有逆转作用。作者对临床上用氯喹常规剂量合并酮替芬或赛庚啶治疗对氯喹抗药性病人的问题进行了讨论,提出进一步合并加服周效磺胺或具作用类似物可能取得更好的数果。氯代丙咪嗪等则被建议用于研究。
The reversal of chloroquine resistance by ketotifen and cyproheptadine was observed in mice infected with a highly resistant strain of Plasmodium chloroquine Aclatobacter Ac-1, with one-fourth of the doses of ketotifen and cyproheptadine being able to counter The chloroquine properties were reversed and the resistant mice were cured by the treatment dose of sensitive strains. Increase the dose insecticidal effect. Differoxanthin the corresponding effect is less and higher toxicity. Pre-or simultaneous addition of protein synthesis inhibitors chloramphenicol or rifampicin did not observe the reversal of chloroquine resistance. The authors discuss the clinical use of conventional doses of chloroquine combined with ketotifen or cyproheptadin resistance in patients with chloroquine resistance issues were proposed to further add the week plus sulfadoxine or with the role of analogues may achieve better results. Chlorimipramine and the like have been proposed for research.