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[期刊论文] 作者：Shengyi Lu,Boxun Lu,
来源：神经科学通报（英文版） 年份：2021
Huntington's disease(HD)is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length(＞35 repea...
[期刊论文] 作者：Hang Zhang,.Ping An,Yiyan Fei,Boxun Lu,
来源：神经科学通报（英文版） 年份：2021
Dear Editor,rnThe selective degradation of specific pathogenic proteins provides exciting strategies for drug discovery.Emerging new concepts such as proteolysi...
[期刊论文] 作者：Yuhua Fu,Ningxie Chen,Ziying Wang,Shouqing Luo,Yu Ding,Boxun Lu,
来源：细胞研究（英文版） 年份：2021
Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging.Here,we de......
Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhance
[期刊论文] 作者：Xiaodan Zhang,Xue Wen,Ismael Al-Ramahi,Juan Botas,Boxun Lu,Yuhua Fu,
来源：神经科学通报（英文版） 年份：2022
Dear Editor,rnAccumulation of misfolded and aggregation-prone proteins is the common hallmark of many neurodegenerative disorders,and lowering the levels of these proteins may provide promising strategies for the potential treatment of some......
[期刊论文] 作者：Hongli Zhao,Jue Zhao,Jiapeng Hou,Siqing Wang,Yu Ding,Boxun Lu,Jian Wang,
来源：蛋白质与细胞 年份：2017
Dear Editor,Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder affecting about 1％ of the worldwide population over the age of 60 (El...
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in
[期刊论文] 作者：Xue Wen,Ping An,Hexuan Li,Zijian Zhou,Yimin Sun,Jian Wang,Lixiang Ma,Boxun Lu,
来源：神经科学通报（英文版） 年份：2020
Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders,includ-ing Huntington disease[caused by expanded CAG repeats(C...
A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i
[会议论文] 作者：James Palacino,Yuwei Yao,Xiaotian Cui,Jiapeng Hou,Boxun Lu,Ismael Al-Ramahi,Juan Botas,Lixiang Ma,
来源：The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份：2014
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A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i
[会议论文] 作者：Yuwei Yao,Xiaotian Cui,Ismael Al-Ramahi,Lixiang Ma,Jiapeng Hou,James Palacino,Juan Botas,Boxun Lu,
来源：The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份：2014
Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder caused by cytotoxicity of the mutant huntingtin (mHtt) protein.While mHtt is ubiqui...
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