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[期刊论文] 作者:Shengyi Lu,Boxun Lu,
来源:神经科学通报(英文版) 年份:2021
Huntington's disease(HD)is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length(>35 repea...
[期刊论文] 作者:Hang Zhang,.Ping An,Yiyan Fei,Boxun Lu,
来源:神经科学通报(英文版) 年份:2021
Dear Editor,rnThe selective degradation of specific pathogenic proteins provides exciting strategies for drug discovery.Emerging new concepts such as proteolysi...
[期刊论文] 作者:Yuhua Fu,Ningxie Chen,Ziying Wang,Shouqing Luo,Yu Ding,Boxun Lu,
来源:细胞研究(英文版) 年份:2021
Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging.Here,we de......
Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhance
[期刊论文] 作者:Xiaodan Zhang,Xue Wen,Ismael Al-Ramahi,Juan Botas,Boxun Lu,Yuhua Fu,
来源:神经科学通报(英文版) 年份:2022
Dear Editor,rnAccumulation of misfolded and aggregation-prone proteins is the common hallmark of many neurodegenerative disorders,and lowering the levels of these proteins may provide promising strategies for the potential treatment of some......
[期刊论文] 作者:Hongli Zhao,Jue Zhao,Jiapeng Hou,Siqing Wang,Yu Ding,Boxun Lu,Jian Wang,
来源:蛋白质与细胞 年份:2017
Dear Editor,Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60 (El...
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in
[期刊论文] 作者:Xue Wen,Ping An,Hexuan Li,Zijian Zhou,Yimin Sun,Jian Wang,Lixiang Ma,Boxun Lu,
来源:神经科学通报(英文版) 年份:2020
Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders,includ-ing Huntington disease[caused by expanded CAG repeats(C...
A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i
[会议论文] 作者:James Palacino,Yuwei Yao,Xiaotian Cui,Jiapeng Hou,Boxun Lu,Ismael Al-Ramahi,Juan Botas,Lixiang Ma,
来源:The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份:2014
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A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i
[会议论文] 作者:Yuwei Yao,Xiaotian Cui,Ismael Al-Ramahi,Lixiang Ma,Jiapeng Hou,James Palacino,Juan Botas,Boxun Lu,
来源:The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份:2014
Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder caused by cytotoxicity of the mutant huntingtin (mHtt) protein.While mHtt is ubiqui...
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