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Monitoring dynamic protein-protein interactions during GABAB receptor mediated IGF-1R transactivatio
[会议论文] 作者：Fa-Jun NAN,Jian-Feng LIU,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Many GPCR agonists can activate receptor-tyrosine-kinases (RTKs) through transactivation, the mechanisms of which are poorly defined.Here, we have investigated IGF-1 receptor (IGF-1R) transactivation...
[期刊论文] 作者：Lin-lin GAN,Lin-hai CHEN,Fa-jun NAN,
来源：中国药理学报（英文版） 年份：2017
α-Ketoglutarate (α-KG),a pivotal metabolite in energy metabolism,has been implicated in nonalcoholic fatty liver disease (NAFLD) and several cancers.It is rec...
Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicilli
[期刊论文] 作者：Chen-Xi Yu,Bing-Yan Wei,Xue-Qing Kong,Cai-Guang Yang,Fa-Jun Nan,
来源：中国化学（英文版） 年份：2021
Methicillin-resistant Staphylococcus aureus (MRSA) has become a major threat on public health because of the increase of clinically isolated strains that exhibi...
[期刊论文] 作者：Yu-ting LU,Yu-feng Xiao,Yu-feng Li,Jia Li,Fa-jun Nan,Jing-ya Li,
来源：中国药理学报（英文版） 年份：2019
Palmitate (PA) exposure induces stress conditions featuring ROS accumulation and upregulation of p62 expression,resulting in autophagic flux blockage and cell a...
[期刊论文] 作者：Hai-ning HU,Ping-zheng ZHOU,Fei CHEN,Min LI,Fa-jun NAN,Zhao-bing GAO,
来源：中国药理学报（英文版） 年份：2013
...
[期刊论文] 作者：Jin-feng YUE,Guan-hua QIAO,Ni LIU,Xue-qin CHEN,Fa-jun NAN,Zhao-bing GAO,
来源：中国药理学报（英文版） 年份：2016
...
,Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with impro
[期刊论文] 作者：Xiao-yin WANG,Shu-yong ZHANG,Jing LI,Hua-nan LIU,Xin XIE,Fa-jun NAN,
来源：中国药理学报（英文版） 年份：2014
...
,Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracen
[期刊论文] 作者：Jin-tao Wang,Yue-ming Zheng,Yue-ting Chen,Min Gu,Zhao-bing Gao,Fa-jun Nan,
来源：中国药理学报（英文版） 年份：2020
Nav1.7 channels are mainly distributed in the peripheral nervous system.Blockade of Nav1.7 channels with small-molecule inhibitors in humans might provide pain...
[会议论文] 作者：Pingzheng Zhou,Haibo Yu,Min Gu,Fa-jun Nan,Zhaobing Gao,Min Li,
来源：上海市细胞生物学学会第十届CST细胞生物学青年论坛 年份：2014
Pharmacological augmentation of neuronal KCNQ muscarinic (M) currents by drugs such as retigabine (RTG) represents a first-in-class therapeutic to treat certain...
Identification of novel KCNQ2 activators using fluorescence-based and automated patch clamp-based hi
[会议论文] 作者：Jin-feng Yue,Guanhua Qiao,Ni Liu,Xueqin Chen,Fa-jun NAN,Zhao-bing GAO,
来源：第十四次全国暨国际生物物理大会 年份：2015
...
[期刊论文] 作者：Yi Liu,Ke-xin Zhu,Lei Cao,Zhi-fu Xie,Min Gu,Wei Lü,Jing-ya Li,Fa-jun Nan,
来源：中国药理学报（英文版） 年份：2020
Berberine (BBR) exhibits diverse bioactivities,including anticancer activity;but its poor druggability limits its applications.In this study,we designed and syn...
,Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal
[期刊论文] 作者：Ling-ling CHEN,Jia LI,Jing-ya LI,Qun-li LUO,Wei-feng MAO,Qiang SHEN,Fa-jun NAN,Qi-zhuang YE,
来源：中国药理学报（英文版） 年份：2004
AIM: To screen antifungal drug candidates using in vitro and in vivo assays based on type I methionine aminopeptidase from Saccharomyces cerevisiae (ScMetAP1)....
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adi
[期刊论文] 作者：Bo-han Li,Mei Zhang,Ya-nan Duan,Lin Shuai,Hao-wen Jiang,Jia Li,Fa-jun Nan,Jing-ya Li,
来源：中国药理学报：英文版 年份：2021
Beige adipocytes have been considered as a potential strategy in anti-obesity therapy because of its thermogenic capacity.AMP-activated protein kinase(AMPK)plays important roles in regulating adipose tissue function.C29 is a novel pyrazolon......
The hit-to-lead optimization of 1,2,3,4,4a,9a-hexahydro-1H-xanthenes as glucocorticoid receptor anta
[期刊论文] 作者：Yan-Hui Zhu,Meng Zhang,Qun-Yi Li,Qing Liu,Jie Zhang,Yun-Yun Yuan,Fa-Jun Nan,Ming-Wei Wang,,
来源：Chinese Chemical Letters 年份：2014
The structure–activity relationship(SAR) study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a(hGRa) antagonists i...
,Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipi
[期刊论文] 作者：XIE,Run-tao ZHANG,Da-kai CHEN,Min GU,Shi-chao CUI,Yang-ming ZHANG,Xin-wen ZHANG,Yan-yan YU,Jia LI,Fa-jun NAN,
来源：中国药理学报（英文版） 年份：2018
Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by hepatic steatosis.NAFLD is closely linked to obesity,insulin resistance and dy...
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced an
[期刊论文] 作者：Xin-wen Zhang,Chen-dong Zhou,Jian-peng Yin,Yan-yan Yu,Shi-chao Cui,Hao-wen Jiang,Teng-teng Li,Jia Li,Fa-jun Nan,
来源：中国药理学报（英文版） 年份：2021
Dyslipidemia is a chronic metabolic disease characterized by elevated levels of lipids in plasma.Recently,various studies demonstrate that the increased activit...
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