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[期刊论文] 作者:Fang-Jie Yan,Mei-Jia Qian,Hong, 来源:TMR现代中药 年份:2018
目的:YAP是Hippo信号通路的关键下游蛋白,受到Hippo激酶LATS1/2的负性调控.作为转录共激活子,YAP可转录激活下游靶基因促进细胞增殖,对调控肿瘤细胞的存活发挥关键的作用,因而...
[期刊论文] 作者:Wei-hua Wang,Tao Yuan,Mei-jia Qian,Fang-jie Yan,Liu Yang,Qiao-jun He,Bo Yang,Jin-jian Lu,Hong Zhu, 来源:中国药理学报(英文版) 年份:2021
Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis.Among them,KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to intervention.Although the cogni......
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