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Val8-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β pe
[会议论文] 作者：Xiao-Hui Wang,Wei Yang,Zhao-Jun Wang,Hong-Yan Cai,Qing-Shan Li,Jin-Shun Qi,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD) in the elderly.Glucagonlike peptide-1 (GLP-1), a modulator used in T2DM therapy, has been shown to have neuroprotective pro...
Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Mode
[期刊论文] 作者：Jun-Ting Yang,Zhao-Jun Wang,Hong-Yan Cai,Li Yuan,Meng-Ming Hu,Mei-Na Wn,Jin-Shun Qi,
来源：神经科学通报（英文版） 年份：2018
Alzheimer\'s disease (AD) is the most common form of dementia among the elderly,characterized by amyloid plaques,neurofibrillary tangles,and neuroinflammation in the brain,as well as impaired cognitive behaviors.A sex difference in the prev......
GLP-1 analogue CJC-1131 Rescues Spatial Cognition and Synaptic Plasticity of Rats from Aβ1-42-induce
[会议论文] 作者：Sheng-Xiao Zhang,Hong-Yan Cai,Jun Zhang,Yu-Wei Zhang,Hui Zhao,Qiong Wang,Song-Jie Ren,Jin-Shun Qi,
来源：中国生理学会第24届全国会员代表大会暨生理学学术大会 年份：2014
Although the amyloid β protein (Aβ) aggregated in the brain has been recognized as one of the main pathological characteristics in Alzheimers disease (AD),the effective strategies against the Aβ neuro...
The Neuroprotective Effects of Rattin Against Neurotoxic Aβ are Involved in JAK/STAT3 and Calcium Ho
[会议论文] 作者：Zhao-Jun Wang,Xiao-Hui Wang,Li Yuan,Mei-Na Wu,Jun Zhang,Hong-Yan Cai,Xiao-Jie Liu,Sheng-Xiao Zhang,Qing-Shan,
来源：中国生理学会第24届全国会员代表大会暨生理学学术大会 年份：2014
Rattin,a humanin-like peptide,shared with Humanin ability to protect neurons against amyloid β protein(Aβ)-induced cellular toxicity.However,it is not well known about its neuroprotective molecular me...
[期刊论文] 作者：Guang-Zhao Yang,Qi-Chao Gao,Wei-Ran Li,Hong-Yan Cai,Hui-Min Zhao,Jian-Ji Wang,Xin-Rui Zhao,Jia-Xin Wang,
来源：中国神经再生研究（英文版） 年份：2022
in our previous studies,we have shown that (D-Ser2) oxyntomodulin (Oxm),a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and s......
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