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[会议论文] 作者:Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque, 来源:全国药物化学学术会议暨第四届中英药物化学学术会议 年份:2013
  A series of C6-rigid S-DABO analogs featured with a substituted benzoyl group at C6 position of the pyrimidine ring has been designed,synthesized and biolog...
[会议论文] 作者:Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque, 来源:全国药物化学学术会议暨第四届中英药物化学学术会议 年份:2013
A series of C6-rigid S-DABO analogs featured with a substituted benzoyl group at C6 position of the pyrimidine ring has been designed,synthesized and biologically evaluated as NNRTIs against wild type...
[会议论文] 作者:Gu,Shuang-Xi,Zhu,Yuan-Yuan,Chen,Fen-Er,Erik De Clercq,Jan Balzarini,Christophe Pannecouque, 来源:中国化学会第八届有机化学学术会议暨首届重庆有机化学国际研讨会 年份:2013
[会议论文] 作者:Xiao Li,Peng Zhan,Erik De Clercq,Jan Balzarini,Christophe Pannecouque,Xinyong Liu, 来源:第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份:2012
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures [1,2],we have employed a scaffold hopping strategy [3] to explore the chemically diverse space of bioac...
[期刊论文] 作者:熊远珍,胡海荣,陈芬儿,Jan Balzarini,Christophe Pannecouque,Erik De Clercq,, 来源:药学学报 年份:2009
在已有工作基础上,基于分子对接设计合成了8个新的4-烯丙基取代和4-叠氮基取代的二芳基三嗪类衍生物。抗HIV-1活性的测试结果表明所有新化合物均具有抗HIV-1活性。其中化合物...
[期刊论文] 作者:Sreekanth Thota,Mohammad Imran,Manasa Udugula,Rajeshwar Yerra,Subhas S.Karki,Jan Balzarini,Erik De Clercq, 来源:Chinese Chemical Letters 年份:2012
The synthesis and spectroscopic characterization of ruthenium complexes(R-l to R-8) of the type[Ru(A)_2(B)],(where A = 1,10-phenanthroline/2,2′-bipyridine and...
[会议论文] 作者:Zi-Hong Yan,Hai-Qiu Wu,Qiu-Qin He,Fen-Er Chen,Erik De Clercq,Jan Balzarini,Christophe Pannecouque, 来源:全国药物化学学术会议暨第四届中英药物化学学术会议 年份:2013
A series of novel diarylpyrimidine with a halogen substituent on the methylene linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell...
[会议论文] 作者:Shuang-Xi GU,Heng QIAO,Yuan-Yuan ZHU,Xiu-Lian JU,Erik DE CLERCQ,Jan BALZARINI,Christophe PANNECOUQUE, 来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Non-nucleoside reverse transcriptase inhibitors(NNRTIs)have received wide attention due to their unique antiviral potency,high specificity and low cytotoxicity[1]....
[会议论文] 作者:Xinyong Liu,Peng Zhan,Xuwang Chen,Wenmin Chen,Ye Tian,Xiao Li,Christophe Pannecouque,Jan Balzarini,Erik, 来源:第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份:2012
Aquired Immune Deficiency Syndrome(AIDS) caused by human immunodeficiency virus(HIV),is still prevalent worldwide.The most efficient and standard treatment regimen for HIV-1 infection,namely as highly...
[期刊论文] 作者:Jie AN,Jin-Zhi LIU,Chuan-Fang WU,Jian LI,Lei DAI,Els Van DAMME,Jan BALZARINI,Erik De CLERCQ,Fang CHEN, 来源:生物化学与生物物理学报(英文版) 年份:2006
The anti-human immunodeficiency virus (HIV) Ⅰ/Ⅱ activity of a mannose and sialic acid binding lectin isolated from rhizomes of Polygonatum cyrtonema Hua was e...
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