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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
[期刊论文] 作者：Shaoyong Lu,Yingyi Chen,Jiacheng Wei,Mingzhu Zhao,Duan Ni,Xinheng He,Jian Zhang,
来源：药学学报（英文版） 年份：2021
The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceu-tical target for aging-related and cancer diseases.Ho......
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migrati
[期刊论文] 作者：Qiufen Zhang,Yingyi Chen,Duan Ni,Zhimin Huang,Jiacheng Wei,Li Feng,Jun-Cheng Su,Yingqing Wei,Shaobo Ning,
来源：药学学报（英文版） 年份：2022
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the ......
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