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[期刊论文] 作者：Jian-Zhi Wang,
来源：神经科学通报（英文版） 年份：2014
Alzheimer\'s disease (AD) is the most common neurodegenerative disorder and is characterized pathologically by the progressive intracellular accumulation of neurofibrillary tangles and extracellular deposition of plaques in the brain.Since ......
[期刊论文] 作者：Jian-zhi WANG,Ze-fen WANG,
来源：中国药理学报（英文版） 年份：2006
Alzheimer disease (AD), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized...
[期刊论文] 作者：Yang Ying,Jian-Zhi Wang,
来源：神经科学通报:英文版 年份：2021
Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no cure.Neural circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with AD.Therefore,it is imp......
[期刊论文] 作者：ZHAO Jian-Zhi,WANG Guang-Wao,LIANG Yong-Cheng,
来源：中国物理快报（英文版） 年份：2008
Based on the first-principles plane-wave basis pseudopotential calculations, we investigate mechanical properties and electronic structures of the hardest known...
[期刊论文] 作者：Jian-Zhi Wang,Zhi-Hao Wang,Qing Tian,
来源：神经科学通报（英文版） 年份：2014
...
[期刊论文] 作者：Ying-chun ZHANG,Ze-fen WANG,Qun WANG,Yi-peng WANG,Jian-zhi WANG,
来源：中国药理学报（英文版） 年份：2004
AIM: To explore the effect of β-amyloid (Aβ) on metabolism of cytoskeletal protein neurofilament, and search for effective cure to the lesion. METHODS: Wild t...
[期刊论文] 作者：Yan-qiu DENG,Guo-gang XU,Ping DUAN,Qi ZHANG,Jian-zhi WANG,
来源：中国药理学报（英文版） 年份：2005
Aim: To explore the underlying mechanism of tau hyperphosphorylation in an Alzheimer’s-affected brain and the possible arresting strategies. Methods: MTT (3-[4...
[期刊论文] 作者：Hai-hong WANG,Ai-hong ZHANG,Ling-qiang ZHU,Qun WANG,Jian-zhi WANG,
来源：中国药理学报（英文版） 年份：2005
Aim: To investigate the effect of dishevelled- 1 (DVL- 1) on wortmannin-induced Alzheimer-like hyperphosphorylation of cytoskeletal proteins in mouse neuroblast...
Prolonged Alzheimer-like Tau Hyperphosphorylation Induced by Simultaneous Inhibition of Phosphoinosi
[期刊论文] 作者：Guo-Gang XU,Yan-Qiu DENG,Shi-Jie LIU,Hong-Lian LI,Jian-Zhi WANG,
来源：生物化学与生物物理学报（英文版） 年份：2005
Co-injection of wortmannin (inhibitor of phosphatidylinositol-3 kinase, PI3K) and GF109203X (inhibitor of protein kinase C, PKC) into the rat brain was found to...
Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated imp
[会议论文] 作者：Ling-Qiang Zhu,Dan Liu,Yang-Yang Yin,Qun Wang,Jian-Zhi Wang,
来源：2009国际分子神经退行性疾病大会(2009 International Conference on molecular 年份：2009
...
Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated imp
[会议论文] 作者：Ling-Qiang Zhu,Dan Liu,Yang-Yang Yin,Qun Wang,Jian-Zhi Wang,
来源：2009国际分子神经退行性疾病大会(2009 International Conference on molecular 年份：2009
...
[期刊论文] 作者：Jing Guo,Shaozhou Ni,Qihang Li,Jian-Zhi Wang,Ying Yang,
来源：神经科学通报（英文版） 年份：2019
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer\'s disease (AD).Visual dysfunction is commonly found and is positively correlated with the severity of cognitive defects in AD patients.Our previous study demonstrated ......
[期刊论文] 作者：Yi-peng WANG,Xian-tao LI,Shi-jie LIU,Xin-wen ZHOU,Xiao-chuan WANG,Jian-zhi WANG,
来源：中国药理学报（英文版） 年份：2004
AIM: To explore the protective effects of melatonin (Mel) on the abnormal phosphorylation of neuronal cytoskeletal proteins. METHODS: We generated a neuroblasto...
INHIBITION OF MELATONIN BIOSYNTHESIS ACTIVATES PROTEIN KINASE A AND INDUCES ALZHEIMER-LIKE TAU HYPER
[期刊论文] 作者：Ling-qiang Zhu,Shao-hui Wang,Zhi-qun Ling,Qun WANG,Mao-qiong Hu,Jian-zhi WANG,
来源：中国医学科学杂志（英文版） 年份：2004
Objective To investigate effect of inhibiting melatonin biosynthesis on activities of protein kinase A (PKA), glycogen synthase kinase-3 (GSK-3) and tau phospho...
[期刊论文] 作者：Yan Xiong,Dan-Ju Luo,Xiu-Lian Wang,Mei Qiu,Yang Yang,Xiong Yan,Jian-Zhi Wang,
来源：神经科学通报（英文版） 年份：2015
...
[期刊论文] 作者：Jiang FANG,Rong LIU,Qing TIAN,Xiao-ping HONG,Shao-hui WANG,Fu-yuan CAO,Xi-ping PAN,Jian-zhi WANG,
来源：中国药理学报（英文版） 年份：2007
Aim:This study was to investigate the effect of dehydroevodiamine (DHED) on Alzheimer’s disease (AD)-like tan hyperphosphorylation induced by calyculin A (CA),...
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in
[期刊论文] 作者：Yao Zhang,Jia-Zhao Xie,Xiang-Yang Xu,Jun Hu,Teng Xu,Si Jin,Shao-Juan Yang,Jian-Zhi Wang,
来源：神经科学通报（英文版） 年份：2019
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer\'s disease (AD),and insulinresistance is commonly seen in patients with Hhcy.Liraglutide (Lir),a glucagon-like peptide that increases the secretion and sensitivity of i......
[期刊论文] 作者：Ye-Hong Du,Xian-Yu Liu,Xin-Yu Wang,Jun-Cai Sun,Qiong-Qiong Lu,Jian-Zhi Wang,Ahmad Omar,Daria Mikhailova,
来源：稀有金属（英文版） 年份：2022
Aqueous rechargeable zinc-ion battery (ZIB) is considered to be a potential energy storage system for large-scale applications due to its environmental friendli-ness,high safety,and low cost.However,it remains challenging to develop suitabl......
[期刊论文] 作者：Yan Xiong,Dan-Ju Luo,Xiu-Lian Wang,Mei Qiu,Yang Yang,Xiong Yan,Jian-Zhi Wang,Qi-Fa Ye,Rong Liu,,
来源：Neuroscience Bulletin 年份：2015
Zinc induces protein phosphatase 2A(PP2A) inactivation and tau hyperphosphorylation through PP2A(tyrosine 307) phosphorylation in cells and the brain, but wheth...
[期刊论文] 作者：HU,Xiao-Chuan WANG,Li-Yun LI,Mai-Li LIU,Rong LIU,Zhiqun LING,Qing TIAN,Xiao-Wei TANG,Yi-Gen WU,Jian-Zhi WANG,
来源：生物化学与生物物理学报（英文版） 年份：2004
To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatia...
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