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,Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug
[期刊论文] 作者:Fei Yi,Guang-Hui Liu,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2012
Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug dis...
[期刊论文] 作者:Ruotong Ren,Juan Carlos Izpisua Belmonte,Guang-Hui Liu,
来源:蛋白质与细胞 年份:2018
Cytidine base editors (CBEs,rAPOBEC1-nCas9-UGI) and adenine base editors (ABEs,TadA-TadA*-nCas9) are newly developed genome-editing tools that have enabled high...
[期刊论文] 作者:ez Delicado,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2020
In this issue,Wang et al.report on the generation of a non-human primate model of Hutchinson-Gilford progeria syn-drome(HGPS)using a base editor.Base editing is...
,Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factor
[期刊论文] 作者:Zhang,Guang-Hui Liu,Fei Yi,Nuria Montserrat,Tomoaki Hishida,Concepcion Rodriguez Esteban,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2014
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Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced p
[期刊论文] 作者:Fei Yi,Jing Qu,Mo Li,Keiichiro Suzuki,Na Young Kim,Guang-Hui Liu,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2012
...
[期刊论文] 作者:S.Wright,Jane Peppard,Paul August,Cecile Volle-Challier,Francoise Bono,Jean-Marc Herbert,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2012
...
[期刊论文] 作者:Zunpeng Liu,Moshi Song,Weiqi Zhang,Si Wang,Xiaoqian Liu,Shuai Ma,Shuhui Sun,Lina Fu,Qun Chu,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2019
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencaphalopathy (CADASIL) is a rare hereditary cerabrovascular disease caused by a NO...
[期刊论文] 作者:Wei,Wei Li,Jinghui Lei,Yu Huang,Yanmei Sang,Piu Chan,Chang Chen,Jing Qu,Keiichiro Suzuki,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2018
Hutchinson-Gilford progeria syndrome (HGPS) and Wemer syndrome (WS) are two of the best characterized human progeroid syndromes.HGPS is caused by a point mutati...
[期刊论文] 作者:Jingyi Li,Yuxuan Zheng,Pengze Yan,Moshi Song,Si Wang,Liang Sun,Zunpeng Liu,Shuai Ma,Juan Carlos Izpisua Belmonte,
来源:国家科学评论(英文版) 年份:2021
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the...
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocard
[期刊论文] 作者:Wang,Wang Kang,Qun Chu,Zunpeng Liu,Liang Sun,Yun Ji,Concepcion Rodriguez Esteban,Yan Yao,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2021
Dear Editor,rnMyocardial infarction(MI)is the irreversible cardiomyocyte death resulting from prolonged oxygen deprivation due to obstructed blood supply(ischem...
[期刊论文] 作者:Jiping Yang,Si Wang,Zhaoxia Wang,Keiichiro Suzuki,Liang Sun,Xiuling Xu,Yang Yu,Jie Qiao,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2017
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described.Mutations in a numbe...
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
[期刊论文] 作者:Zeming Wu,Zehua Wang,Qiaoran Wang,Si Wang,Kaowen Yan,Liang Sun,Tomoaki Hishida,Yanning Cai,Juan Carlos Izpisua Belmonte,
来源:细胞研究(英文版) 年份:2021
Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadia...
[期刊论文] 作者:Zhaohao Huang,Jinguo Ye,Wen Shi,Yanxia Ye,Zunpeng Liu,Moshi Song,Weiqi Zhang,Jing-Dong J.Han,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2020
Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that hu...
[期刊论文] 作者:Ma,Weiqi Zhang,Yang Yu,Yusheng Cai,Kaowen Yan,Wei Li,Baoyang Hu,Piu Chan,Guo-Guang Zhao,Juan Carlos Izpisua Belmonte,
来源:蛋白质与细胞 年份:2021
The hippocampus plays a crucial role in leaming and mem-ory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hip-po......
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