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,Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug
[期刊论文] 作者：Fei Yi,Guang-Hui Liu,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2012
Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug dis...
[期刊论文] 作者：Ruotong Ren,Juan Carlos Izpisua Belmonte,Guang-Hui Liu,
来源：蛋白质与细胞 年份：2018
Cytidine base editors (CBEs,rAPOBEC1-nCas9-UGI) and adenine base editors (ABEs,TadA-TadA*-nCas9) are newly developed genome-editing tools that have enabled high...
[期刊论文] 作者：ez Delicado,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2020
In this issue,Wang et al.report on the generation of a non-human primate model of Hutchinson-Gilford progeria syn-drome(HGPS)using a base editor.Base editing is...
,Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factor
[期刊论文] 作者：Zhang,Guang-Hui Liu,Fei Yi,Nuria Montserrat,Tomoaki Hishida,Concepcion Rodriguez Esteban,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2014
...
Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced p
[期刊论文] 作者：Fei Yi,Jing Qu,Mo Li,Keiichiro Suzuki,Na Young Kim,Guang-Hui Liu,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2012
...
[期刊论文] 作者：S.Wright,Jane Peppard,Paul August,Cecile Volle-Challier,Francoise Bono,Jean-Marc Herbert,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2012
...
[期刊论文] 作者：Zunpeng Liu,Moshi Song,Weiqi Zhang,Si Wang,Xiaoqian Liu,Shuai Ma,Shuhui Sun,Lina Fu,Qun Chu,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2019
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencaphalopathy (CADASIL) is a rare hereditary cerabrovascular disease caused by a NO...
[期刊论文] 作者：Wei,Wei Li,Jinghui Lei,Yu Huang,Yanmei Sang,Piu Chan,Chang Chen,Jing Qu,Keiichiro Suzuki,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2018
Hutchinson-Gilford progeria syndrome (HGPS) and Wemer syndrome (WS) are two of the best characterized human progeroid syndromes.HGPS is caused by a point mutati...
[期刊论文] 作者：Jingyi Li,Yuxuan Zheng,Pengze Yan,Moshi Song,Si Wang,Liang Sun,Zunpeng Liu,Shuai Ma,Juan Carlos Izpisua Belmonte,
来源：国家科学评论（英文版） 年份：2021
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the...
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocard
[期刊论文] 作者：Wang,Wang Kang,Qun Chu,Zunpeng Liu,Liang Sun,Yun Ji,Concepcion Rodriguez Esteban,Yan Yao,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2021
Dear Editor,rnMyocardial infarction(MI)is the irreversible cardiomyocyte death resulting from prolonged oxygen deprivation due to obstructed blood supply(ischem...
[期刊论文] 作者：Jiping Yang,Si Wang,Zhaoxia Wang,Keiichiro Suzuki,Liang Sun,Xiuling Xu,Yang Yu,Jie Qiao,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2017
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described.Mutations in a numbe...
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
[期刊论文] 作者：Zeming Wu,Zehua Wang,Qiaoran Wang,Si Wang,Kaowen Yan,Liang Sun,Tomoaki Hishida,Yanning Cai,Juan Carlos Izpisua Belmonte,
来源：细胞研究（英文版） 年份：2021
Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadia...
[期刊论文] 作者：Zhaohao Huang,Jinguo Ye,Wen Shi,Yanxia Ye,Zunpeng Liu,Moshi Song,Weiqi Zhang,Jing-Dong J.Han,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2020
Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that hu...
[期刊论文] 作者：Ma,Weiqi Zhang,Yang Yu,Yusheng Cai,Kaowen Yan,Wei Li,Baoyang Hu,Piu Chan,Guo-Guang Zhao,Juan Carlos Izpisua Belmonte,
来源：蛋白质与细胞 年份：2021
The hippocampus plays a crucial role in leaming and mem-ory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hip-po......
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