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[会议论文] 作者：Yu-Ting Lu,Yong-Rao,Zhi-Shu Huang,Lian-Quan Gu,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep...
Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者：Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源：2013中国药学大会暨第十三届中国药师周 年份：2013
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Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者：Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源：2013中国药学大会暨第十三届中国药师周 年份：2013
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BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者：Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：第13届亚洲化学大会(13th Asian Chemical Congress) 年份：2009
...
BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者：Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：第13届亚洲化学大会(13th Asian Chemical Congress) 年份：2009
...
Specific Recognition of Quindoline Derivatives on Promoter G-Quadruplex and the Biological Relevance
[会议论文] 作者：Tian-miao Ou,Yue Wu,Jia-heng Tan,Lian-quan Gu,Zhi-shu Huang,
来源：第八届全国化学生物学学术会议 年份：2013
G-quadruplexes are unique secondary structure exist in various non-coding region of human genome and exhibit important biological roles in the regulation of gene replication, transcription, and transl...
Exploration of the Mechanism for Isoliquiritigenin Derivatives Inhibiting Aβ(1-42)Self-aggregation A
[会议论文] 作者：Yi-Ping Chen,Ling Wang,Jun Xu,Zhi-Shu Huang,Lian-Quan Gu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of new isoliquiritigenin(ISL)derivatives were synthesized and evaluated as inhibitors for amyloid-beta(Aβ)aggregation.It was found that all these synthetic compounds inhibited Aβ(1-42)self-ag...
Synthesis and Evaluation of Acridine Derivatives as a New Class of Selectively Ligands to Binding c-
[会议论文] 作者：Sheng-rong Liao,Si-tian Zhuo,Peng-hui Li,Lian-quan Gu,Zhi-shu Huang,
来源：第七届全国化学生物学学术会议 年份：2011
The nuclease hypersensitivity element (NHE) Ⅲ1 upstream of the P1 promoter that controls 85-90% of the human c-myc promoter transcriptional activation has been attracted considerable research over the...
Catalytic inhibition of DNA topoisomerase Ⅱ and induction of apoptosis by novel Carbazole-based agen
[会议论文] 作者：Chun-Yan Li,Hua-Ting Xie,Zhen-Quan Liu,Shi-Liang Huang,Zhu-Shu Huang,Lian-Quan Gu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
DNA topoisomerase Ⅱ(TopoⅡ)are the targets of a variety of clinical agents which can manage the topological state of DNA.TopoⅡ poisons,such as Etoposide,induce tumor cell death by causing DNA strand br...
Small-Molecule-Induced Transcription Repression through Interfering with NM23-H2 Binding to G-quadru
[会议论文] 作者：Jing Lin,Chan Shan,Tian-Miao Ou,Jin-Qiang Hou,Shuo-bin Chen,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
NM23-H2 protein is identified as a transcriptional factor of the important oncogene c-myc,that can bind specifically to defined DNA sequences to promote gene transcription.However,due to its role in t...
[会议论文] 作者：Jin-Wu Yan,Wen-Jie Ye,Yan-ping Li,Jin-Qiang Hou,Jian-Hui Li,Jia-heng Tan,Tian-Miao Ou,Lian-Quan Gu,Zhi-Shu,
来源：第七届全国化学生物学学术会议 年份：2011
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Discovery of Novel Anti-tumour Agents for Specific Recognizing the G-quadruplex in 5-Untranslated Re
[会议论文] 作者：Xiao-Qin Wang,Guo-Tao Kuang,Qi Zhang,Giulia Biffi,Shu-Ling Lin,Hui-Yun Liu,Jia-Heng Tan,Zhi-Shu Huang,Lian-Quan Gu,
来源：第九届全国核糖核酸(RNA)学术讨论会 年份：2016
Angiogenesis is important in tumorigenesis and tumor progress.Human vascular endothelial growth factor(hVEGF)is an angiogenic growth factor that plays a cru...
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