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,Salvicine,a novel topoisomerase Ⅱ inhibitor, exerts its potent anticancer activity by ROS generatio
[期刊论文] 作者：Ling-hua MENG,Jian DING,
来源：中国药理学报（英文版） 年份：2007
Salvicine is a novel diterpenoid quinone compound obtained by structural modi-fication of a natural product lead isolated from a Chinese herb with potent growth...
[期刊论文] 作者：Hui Xing,Ling-hua Meng,
来源：中国药理学报（英文版） 年份：2020
Cancer is a highly heterogeneous disease in term of molecular signature even though it is originated from the same tissue type.Cancer heterogeneity may occur du...
[期刊论文] 作者：Pu Sun,Ling-hua Meng,
来源：中国药理学报（英文版） 年份：2020
Immune system-mediated tumor killing has revolutionized anti-tumor therapies,providing long-term and durable responses in some patients.The phosphoinositide 3-k...
[期刊论文] 作者：Ling-hua MENG,XF Steven ZHENG,
来源：中国药理学报（英文版） 年份：2015
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[期刊论文] 作者：Xiang WANG,Jian DING,Ling-hua MENG,
来源：中国药理学报（英文版） 年份：2015
...
[期刊论文] 作者：Xue-ling LIU,Jian DING,Ling-hua MENG,
来源：中国药理学报（英文版） 年份：2018
Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling.Initially,OIS was th...
[期刊论文] 作者：Xiang WANG,Jia-peng LI,Yan YANG,Jian DING,Ling-hua MENG,
来源：中国药理学报（英文版） 年份：2013
...
,The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating
[期刊论文] 作者：Jia-jie SHI,Si-meng CHEN,Chen-liang GUO,Yi-xue LI,Jian DING,Ling-hua MENG,
来源：中国药理学报（英文版） 年份：2018
Tamoxifen,an important endocrine therapeutic agent,is widely used for the treatment of estrogen receptor positive (ER+) breast cancer.However,de novo or acquire...
[会议论文] 作者：Meng Wu,Zi-Wen Wang,Yu-Xiu Liu,Ao Zhang,Ling-Hua Meng,Qing-Min Wang,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Salification is most commonly employed for modifying physical and chemical properties.However,there are few reports about the differences in biological activity between different salt forms and free a...
,Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitor
[期刊论文] 作者：Wei Guo,Sheng Yao,Pu Sun,Tian-biao Yang,Chun-ping Tang,Ming-yue Zheng,Yang Ye,Ling-hua Meng,
来源：中国药理学报（英文版） 年份：2020
Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as a promising therapeutic target for the treatment of malignant tumors characterized by dysregulated tryptopha...
Discovery of a Novel Series of 7-azaindole scaffold derivatives as PI3K inhibitors with potent activ
[会议论文] 作者：Chengbin Yang,Xi Zhang,Yi Wang,Yongtai Yang,Xiaofeng Liu,Mingli Deng,Yu Jia,Yun Ling,Ling-hua Meng,Yaming,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
The phosphoinositide 3-kinase(PI3K)inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR,[1-3] which provides a promising new approach for the...
[期刊论文] 作者：Gui-min WANG,Xiang WANG,Jian-ming ZHU,Bin-bin GUO,Zhuo YANG,Zhi-jian XU,Bo LI,He-yao WANG,Ling-hua MENG,
来源：中国药理学报（英文版） 年份：2017
The mutation of B-RafV600E is widespread in a variety of human cancers.Its inhibitors vemurafenib and dabrafenib have been launched as drugs for treating unrese...
SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lym
[期刊论文] 作者：Sun,Dong-ze Lin,Yi Chen,Yu-xiang Wang,Zu-wen Zhou,Yan-xin Liu,Li-hua Jiang,Mei-yu Geng,Jian Ding,Ling-hua Meng,
来源：中国药理学报（英文版） 年份：2022
PI3Kδ is expressed predominately in leukocytes and overexpressed in B-cell-related malignances.PI3Kδ has been validated as a promising target for cancer therapy,and specific PI3Kδ inhibitors were approved for clinical practice.However,th......
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