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[期刊论文] 作者：Liu Mixin,Wu Zhuping,Yang Chengdui,Liu Guowen,
来源：质谱学报 年份：2000
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[会议论文] 作者：DENG Qinghua,LI Xinwei,WANG Zhe,LIU Guowen,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
Fatty liver is a major metabolic disorder that occurs during early lactation in high-producing dairy cows.Sterol regulatory element-binding protein-1c (SREBP-1c) is an important transcription factor t...
Non-esterified fatty acids induce expression and secretion of angiopoietin-like protein 4 in calf he
[会议论文] 作者：WANG Jianguo,ZHAO Baoyu,LIU Guowen,WANG Zhe,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
[Background/Aims]An elevated concentration of plasma non-esterified fatty acids (NEFA) is an important indicator of negative energy balance (NEB), which is often associated with metabolic diseases suc...
[会议论文] 作者：YIN Liheng,QIN Xia,LIU Guowen,LI Xinwei,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
Serious lipid mobilization in adipose tissue of dairy cow is the pathological basis of ketosis and fatty liver.Many studies demonstrated that pre-adipocytes are unstable and can differentiate into mul...
Changes of serum biochemical parameters in periparturient dairy cows and cows with subclinical hypoc
[会议论文] 作者：WANG Jianguo,LI Xiaobing,ZHAO Baoyu,LIU Guowen,WANG Zhe,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
Subclinical hypocalcemia is a common metabolic disorder of dairy cows that occurs during early lactation.Many studies have focused on the involvement of calcitropic hormones in hypocalcemia;however,li...
Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured bovin
[会议论文] 作者：DING Hongyan,LI Yu,LI Xinwei,WANG Zhe,LIU Guowen,LI Xiaobing,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
Insulin plays a pivotal role in the regulation of lipid metabolism.However, the mechanism of insulin action on lipid metabolism is still completely unclear in dairy cows.Hepatocytes were isolated from...
NEFA induce dairy cows hepatocytes apoptosis through mitochondrial-mediated ROS-JNK/ERK signaling pa
[会议论文] 作者：LI Yu,DING Hongyan,LI Xinwei,LI Xiaobing,WANG Zhe,LIU Guowen,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
Elevated plasma nonesterified fatty acids (NEFA) and hepatocytes damage are features of ketosis in dairy cows.Oxidative stress is involved in the pathogenesis of liver damage induced by NEFA.However,...
Microplastics in the South China Sea:Level,Inventory and the Impact of Hydrologic Process and Atmosp
[会议论文] 作者：Minggang Cai,Haixia He,Mengyang Liu,Guowen Tang,Weimin Wang,Kai Chen,Yan Lin,
来源：第九届全国环境化学大会 年份：2017
As a new type of pollutant,microplastics(plastics with sizes smaller than 5.0 mm)have drawn increasing attention due to its toxicity leached from itself,desorption of persistent,bioaccumulative and to...
Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in hepatocytes of dairy c
[会议论文] 作者：LI Yu,DING Hongyan,LI Xiaobing,WANG Zhe,LIU Guowen,LI Xinwei,WU Jinjie,WANG Xichun,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
Dairy cows with type Ⅱ ketosis displayed hepatic fat accumulation and hyperinsulinemia, while the underlying mechanism was still completely unclear.This study was aimed to investigate the regulation a...
NEFAs activate the oxidative stress-mediated NF-κB signaling pathway to induce inflammatory response
[会议论文] 作者：ZHAO Chenxu,WANG Yazhou,LIU Huan,ZHANG Min,LEI Lin,DU Xiliang,LIU Guowen,LI Xinwei,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
Non-esterified fatty acids (NEFAs) are important induction factors of inflammatory responses in some metabolic diseases.High plasma levels of NEFAs and oxidative stress exist in the dairy cows with ke...
β-Hydroxybutyrate activates the NF-signaling pathway to promote the expression of pro-inflammatory f
[会议论文] 作者：SHI Xiaoxia,LI Xinwei,LI Dangdang,LI Yu,SONG Yuxiang,DENG Qinghua,WANG Zhe,LI Xiaobing,LIU Guowen,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
β-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis.Dairy cows with ketosis often undergo oxidative stress.BHBA is related to the inflammation involved in other diseases of dai...
Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocy
[会议论文] 作者：SONG Yuxiang,LI Xinwei,LI Na,SHI Xiaoxia,DING Hongyan,ZHANG Yuhang,LI Xiaobing,LIU Guowen,WANG Zhe,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
A high plasma concentration of non-esterified fatty acids (NEFAs) is an important pathogenic factor that leads to ketosis and fatty liver in dairy cows.NEFAs may be associated with oxidative stress in...
[会议论文] 作者：ZHANG Min,ZHANG Renhe,LEI Lin,DU Xiliang,GAO Wenwen,ZHANG Shiqi,LIU Guowen,LI Xiaobing,LI Xinwei,
来源：中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 年份：2015
β-hydroxybutyrate (BHBA) is utilized as precursors of de novo synthesized fatty acids in mammary gland of dairy cows.Butyric acid is absorbed and metabolized into BHBA by ruminal epithelium cells.Howe...
[会议论文] 作者：Li Peng,李鹏,Liu Minyue,刘敏跃,Guo Yang,郭洋,Liu Guowen,Wang Zhe,刘国文,王哲,
来源：中国畜牧兽医学会第三届中国兽医临床大会 年份：2012
乙酰辅酶A羧化酶(ACC)在奶牛肝脏中脂肪酸的合成及氧化代谢过程中起着关键作用,ACCmRNA的表达水平对于研究奶牛酮病、脂肪肝等物质代谢障碍性疾病具有重要影响。本研究采...
[会议论文] 作者：Li Peng,李鹏,Liu Minyue,刘敏跃,Guo Yang,郭洋,Liu Guowen,刘国文,Wang Zhe,王哲,
来源：中国畜牧兽医学会第三届中国兽医临床大会 年份：2012
乙酰辅酶A羧化酶(ACC)在奶牛肝脏中脂肪酸的合成及氧化代谢过程中起着关键作用,ACCmRNA的表达水平对于研究奶牛酮病、脂肪肝等物质代谢障碍性疾病具有重要影响。本研究采用双标准曲线法,成功建立了奶牛ACC基因荧光定量检测方法。结果表明,建立的SYBRGreen Ⅰ 荧......
[会议论文] 作者：Yunhe,ZHOU Ershun,WEI Zhengkai,SONG Xiaojing,LIU Zhicheng,WANG Tiancheng,WANG Wei,ZHANG Naisheng,LIU Guowen,
来源：中国畜牧兽医学会家畜内科学会2014年学术研讨会 年份：2014
The aim of this study was to investigate the effect of glycyrrhizin on LPS-induced endotoxemia in mice and clarify the possible mechanism.An LPS-induced endotoxemia mouse model was used to confirm the...
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