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[期刊论文] 作者:Xiaojuan He,Moshi Song,Jing Qu,Yansu Guo,Heqi Cao,Ruijuan Sun,Guang-Hui Liu,Yong Shen,Major Program Expert,
来源:蛋白质与细胞 年份:2019
Based on a national survey conducted by the National Bureau of Statistics, Chinas elderly population (aged 60 and above) had reached 249 million by the end of 2...
[期刊论文] 作者:Shijia Bi,Zunpeng Liu,Zeming Wu,Zehua Wang,Xiaoqian Liu,Si Wang,Jie Ren,Yan Yao,Weiqi Zhang,Moshi Song,
来源:蛋白质与细胞 年份:2020
SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell p...
,CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeost
[期刊论文] 作者:Zunpeng Liu,Xiaoqian Zhang,Jingyi Li,Liang Sun,Zhenyu Ju,Jian Li,Piu Chan,Guang-Hui Liu,Weiqi Zhang,Moshi Song,
来源:蛋白质与细胞 年份:2018
Vascular cell functionality is critical to blood vessel homeostasis.Constitutive NF-κB activation in vascular cells results in chronic vascular inflammation,le...
[期刊论文] 作者:Lingling Geng,Zunpeng Liu,Si Wang,Shuhui Sun,Shuai Ma,Xiaoqian Liu,Piu Chan,Liang Sun,Moshi Song,Weiqi,
来源:蛋白质与细胞 年份:2019
Dear Editor,Aging is the leading risk factor for many chronic diseases,accounting for almost 60% of all deaths worldwide.How to achieve healthy aging,alleviate a...
[期刊论文] 作者:Zeming WU,Xiaoqian Liu,Sheng Zhang,Qianzhao Ji,Xiaoyu Jiang,Zunpeng Liu,Si Wang,Jing Qu,Weiqi Zhang,Moshi Song,
来源:蛋白质与细胞 年份:2020
Dear Editor,rnAs the most prevalent DNA methylation modification in prokaryotes, DNA N6-methyladenosine (6mA)in eukaryotic genomes has recently been observed in...
[期刊论文] 作者:Fang Cheng,Si Wang,Moshi Song,Zunpeng Liu,Ping Liu,Lei Wang,Yanjiang Wang,Qian Zhao,Kaowen Yan,Piu Chan,
来源:蛋白质与细胞 年份:2019
Dear Editor,Safeguarding cellular redox homeostasis is crucial for maintaining organism health and preventing diseases.Oxidative stress,often characterized by d...
[期刊论文] 作者:Weiqi Zhang,Wei Li,Zeming Wu,Wei Wang,Ruotong Ren,Yao Su,Peichang Wang,Liang Sun,Zhenyu Ju,Piu Chan,Moshi Song,
来源:蛋白质与细胞 年份:2019
Aging increases the risk of various diseases.The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases.In t...
[期刊论文] 作者:Chen Ling,Zunpeng Liu,Moshi Song,Weiqi Zhang,Si Wang,Xiaoqian Liu,Shuai Ma,Shuhui Sun,Lina Fu,Qun Chu,
来源:蛋白质与细胞 年份:2019
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencaphalopathy (CADASIL) is a rare hereditary cerabrovascular disease caused by a NO...
[期刊论文] 作者:Zeming Wu,Weiqi Zhang,Moshi Song,Wei Wang,Gang Wei,Wei Li,Jinghui Lei,Yu Huang,Yanmei Sang,Piu Chan,Chang,
来源:蛋白质与细胞 年份:2018
Hutchinson-Gilford progeria syndrome (HGPS) and Wemer syndrome (WS) are two of the best characterized human progeroid syndromes.HGPS is caused by a point mutati...
[期刊论文] 作者:Jingyi Li,Yuxuan Zheng,Pengze Yan,Moshi Song,Si Wang,Liang Sun,Zunpeng Liu,Shuai Ma,Juan Carlos Izpisua,
来源:国家科学评论(英文版) 年份:2021
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the...
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocard
[期刊论文] 作者:Concepcion Rodriguez Esteban,Yan Yao,Juan Carlos Izpisua Belmonte,Piu Chan,Guang-Hui Liu,Weiqi Zhang,Moshi Song,
来源:蛋白质与细胞 年份:2021
Dear Editor,rnMyocardial infarction(MI)is the irreversible cardiomyocyte death resulting from prolonged oxygen deprivation due to obstructed blood supply(ischem...
,Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis
[期刊论文] 作者:Xiaojuan He,Shuhui Sun,Shuai Ma,Ng Shyh-Chang,Feng Liu,Qiang Wang,Xiaoqun Wang,Lin Liu,Weiqi Zhang,Moshi Song,
来源:蛋白质与细胞 年份:2019
RAP1 is a well-known telomere-binding protein,but its functions in human stem cells have remained unclear.Here we generated RAP1-deficient human embryonic stem...
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
[期刊论文] 作者:Chuqian Liang,Zunpeng Liu,Moshi Song,Wei Li,Zeming Wu,Zehua Wang,Qiaoran Wang,Si Wang,Kaowen Yan,Liang,
来源:细胞研究(英文版) 年份:2021
Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadia...
[期刊论文] 作者:,Lihui Xie,He Li,Wen Wen,Si Wang,Shuai Ma,Zhaohao Huang,Jinguo Ye,Wen Shi,Yanxia Ye,Zunpeng Liu,Moshi Song,
来源:蛋白质与细胞 年份:2020
Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that hu...
[期刊论文] 作者:Si Wang,Yuxuan Zheng,Qingqing Li,Xiaojuan He,Ruotong Ren,Weiqi Zhang,Moshi Song,Huifang Hu,Feifei Liu,
来源:蛋白质与细胞 年份:2021
Dear Editor,rnThe retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment i......
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