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Determination of a novel phosphodiesterase-4 inhibitor chlorbipram in mouse plasma and brain by UFLC
[会议论文] 作者：LI Yi-wen,XU Jiang-ping,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE In this study,we evaluated a simple and sensitive method for determination of a novel phosphodiesterase-4(PDE4)inhibitor,chlorbipram,in mouse plas...
FFPM,a PDE4 inhibitor,recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CREB/BDNF
[会议论文] 作者：GUO Hai-biao,XU Jiang-ping,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE In this study,we investigated the effect of FFPM,a novel PDE4 inhibitor,on learning and memory deficits as well as the underlying mechanism in APP/PS1 transgenic mouse model of Alzheimer dis...
Effects of Yizhi Capsule (益智胶囊) on Learning and Memory Disorder and β-amyloid Peptide Induced Neurot
[期刊论文] 作者：WU Hang-yu,XU Jiang-ping,LI Li,
来源：中国结合医学杂志（英文版） 年份：2004
Objective: To explore the effects of Yizhi Capsule (益智胶囊, YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats. Methods...
Effects of Yizhi Capsule (益智胶囊) on Learning and Memory Disorder and β-amyloid Peptide Induced Neurot
[期刊论文] 作者：WU Hang-yu,XU Jiang-ping,LI Li,
来源：中国结合医学杂志（英文版） 年份：2006
Objective: To explore the effects of Yizhi Capsule (益智胶囊, YZC) on leing and memory disorder and β-amyloid peptide induced neurotoxicity in rats. Methods: V...
Involvement of PI3KAktFoxO3a and PKACREB signaling pathways in protective effect of fluoxetine again
[会议论文] 作者：ZENG Bing-qing,WANG Hai-tao,XU Jiang-ping,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE Phosphatidylinositol-3-kinase/protein kinase B/forkhead box O3a(PI3K/Akt/FoxO3a)signaling pathway plays a critical role in mediating neuronal cell...
MicroRNA-mediated knockdown of the phosphodiesterase4D (PDE4D) enzyme reversed Aβ42-induced memory d
[会议论文] 作者：ZHANG Cong,ZHANG Han-ting,XU Jiang-ping,
来源：第十五届中国神经精神药理学学术会议 年份：2012
OBJECTIVE Here we examined whether long form PDE4Ds reversed memory impairment produced by A β1-42(Aβ42).METHODS Morris water-maze and novelty object recognition tests were used for memory measurement...
Synthesis, Crystal Structure and Antitumor Activity of 6-Chloro-1-((6-chloropyridin-3-yl)methyl)-3-p
[期刊论文] 作者：SHI Xiu-Dong,GE Bing-Chen,XU Jiang-Ping,ZHOU Zhong-Zhen,
来源：黑龙江科技信息 年份：2016
本文通过对荣华二采区10...
[期刊论文] 作者：ZHANG Cong,CHENG Yu-fang,NIU Bo,XU Jiang-ping,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE To examine whether long-form phosphodiesterase-4 (PDE4) knockdown by lentiviral RNA construct containing a specific microRNA/miRNAmir hairpin structure reversed depression-like symptoms caus...
A Novel Mechanism Underlying the Protective Effect of PDE4 Inhibitor Against Cognitive Impairment:In
[期刊论文] 作者：YOU Ting-ting,GUO Hai-biao,WANG Hai-tao,XU Jiang-ping,,
来源：神经药理学报 年份：2017
Background:Inhibition of phosphodiesterase 4(PDE4)improves the leing and memory abilities in Alzheimers disease animal models. The cognition-enhancing effects o...
[会议论文] 作者：JIN Zeng-liang,CHENG Yu-fang,ZHOU Dan,XU Jiang-ping,
来源：第十五届中国神经精神药理学学术会议 年份：2012
OBJECTIVE Fructus Akebiae (FAE) is a tradi tional Chinese herbal that has been used for the treatment of de pressive disorders in China.To determine the content of heder agenin and identify the substa...
[会议论文] 作者：ZHUO Ren-gong,MA Xiao-yun,LIU Xiao-yan,XU Jiang-ping,ZHENG Jian-quan,
来源：第十五届中国神经精神药理学学术会议 年份：2012
MrgD is expressed almost exclusively in dorsal root ganglion (DRG) neurons.And its activation inhibited KCNQ/M-currents that contributes to an increase in excitability of DRG neurons and thus nay enha...
[会议论文] 作者：YOU Ting-ting,ZENG Bing-qing,LI Yi-wen,CHENG Yu-fang,XU Jiang-ping,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE Neuroinflammation involes in the pathogenesis of mental disorders and neurodegenerative disorders of central nerve system(CNS).Studies have shown that cAMP induced autophagy whereas autophag...
FCPR16 induces AMPK-dependent autophagy and provides neuroprotection in SH-SY5Y cells and neurons ex
[会议论文] 作者：ZHONG Jia-hong,XIE Jin-feng,XIAO Jiao,ZHOU Zhong-zhen,WANG Hai-tao,XU Jiang-ping,
来源：2019全国老年痴呆与认知障碍相关疾病学术大会 年份：2019
OBJECTIVE The cause of Parkinson disease(PD)is generally not clear,but it is considered to be related to excessive oxidative damage....
[期刊论文] 作者：LIU Xin,WEN Rui-ting,GONG Mei-fang,XU Ying,Nicolas GRAHAME,XU Jiang-ping,LIANG Jian-hui,Marco CONTI,张汉霆,
来源：中国药理学与毒理学杂志 年份：2017
OBJECTIVE Alcoholism is one of the most damaging psychiatric disorders and causes serious social and health problems in the world. However,there are no ideal tr...
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