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Synthesis of Site specifically Phosphate-caged siRNAs and Evaluation of their RNAi Activity and Stab
[会议论文] 作者：Xinjing Tang,
来源：中国化学会第29届学术年会 年份：2014
A complete set of new photolabile nucleoside phosphoramidites were synthesized and then site-specifically incorporated in a siRNA strands for phosphate caging.Single caging modification was made along...
[会议论文] 作者：Yuan Wang,Xinjing Tang,
来源：中国化学会第30届学术年会 年份：2016
Small interfering RNAs(siRNAs)play important roles in gene function study and drug development.Recently,chemical modifications of siRNAs on backbone have be...
[会议论文] 作者：Junzhou Wu,Xinjing Tang,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Here we present a study on enzymatic incorporation of two photolabile deoxyuridine triphosphates.These two nucleotides bearing photocaged amine and carboxylic acid at position 5 of deoxyuridine were s...
Synthesis and Unique Photoluminescence Properties of Novel Nitrogen-rich Quantum dots and Their Appl
[会议论文] 作者：Xinjing Tang,Xiuxian Chen,zhisheng Wu,Qingqing Jin,
来源：The 6th International Conference on Nanoscience and Technolo 年份：2015
New carbon based quantum dots have been discovered and investigated,such as nanodiamonds,graphene oxide(GOD),C-dots.[1] Compared to traditional semiconductor quantum dots,carbon based nanostructures(s...
Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silen
[会议论文] 作者：Xinjing Tang,Changmai Chen,Zhongyu Wang,Jinhao Zhang,Xinli Fan,Luzheng Xu,
来源：第十一届全国化学生物学学术会议 年份：2019
Caged RNAs featuring dextran conjugation of antisense and sense RNA strands using photolabile linker were rationally designed and self-assembled to form cag...
[会议论文] 作者：Xiuxian Chen,Zhisheng Wu,Qingqing Jin,Lizhu Wu,ChenHo Tung,Xinjing Tang,
来源：The Asian Pacific Conference on Chemistry of Materials 2015 年份：2015
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[会议论文] 作者：Li Wu,Yuan Wang,Junzhou Wu,Cong Lv,Jie Wang,Xinjing Tang,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
In the thesis,we synthesized three 20mer caged circular asODNs(R20,R20B2 and R20B4) with a photocleavable linker and an amide bond linker between two 10mer ODNs.With these caged circular asODNs,RNA bi...
[会议论文] 作者：Li WU,Fen PEI,Jinhao ZhANG,Junzhou WU,Mengke FENG,Yuan WANG,Hongwei JIN,Liangren ZhANG,Xinjing Tang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
A complete set of new phospate-caged photolabile nucleoside phosphoramidites were synthesized,and were then site-specifically incorporated into sense or antisense strands of a siRNA.Single caging modi...
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