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Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pat
[期刊论文] 作者：Department of Pharmacy,Xuanwu Hospital of Capital Medical University;Key Laboratory for Neurodegenerative,
来源：当代医学科学（英文） 年份：2020
rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer\'s disease(AD).Besides cognitive impairments,rTg4510 mice also show abnormal hyperactivity behavior.C......
Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgeni
[期刊论文] 作者：Department of Pharmacy, Xuanwu Hospital of Capital Medical University;Key Laboratory for Neurodegenerative,
来源：当代医学科学（英文） 年份：2021
Cognitive impairment is the main clinical manifestation of Alzheimer\'s disease (AD),and amyloid-β (Aβ) deposition and senile plaques are the characteristic neuropathological hallmarks in AD brains.This study aimed to explore the effect a......
Cornel Iridoid Glycoside Regulates Modification of Tau and Alleviates Synaptic Abnormalities in Aged
[期刊论文] 作者：Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center,
来源：当代医学科学（英文） 年份：2020
Alzheimer\'s disease(AD),also defined as a tauopathology,is a common neurodegenerative disease.Hyper-phosphorylation,cleavage or truncation,and aggregation of tau contribute to AD.Thus,targeting the post-translational modifications on tau m......
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