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Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR
[期刊论文] 作者：Hacer Karatas,Shirley Y.Lee,Elizabeth C.Townsend,Fang Cao,Jing Xu,Denzil Bernard,Liu Liu,Yali Dou,Shaomeng,
来源：Chinese Chemical Letters 年份：2015
We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–prote...
[会议论文] 作者：Xiaonan Su,Guixin Zhu,Shuang Yang,Xiaozhe Ding,Shirley Y.Lee,Yali Dou,Bing Zhu,Wei Wu,Haitao Li,
来源：第四届国际肿瘤表观遗传学大会 年份：2014
Histone modification pattern and its combinatorial readout emerge as a fundamental mechanism for epigenetic regulation.Here we characterized Spindlin1 as a histone effector that senses a cistail histo...
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