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[会议论文] 作者：Qian-Na Zhan,Jin-Lian Ma,Yi-Chao Zheng,Wen Zhao,Hong-Min Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Histone lysine-specific demethylase 1(LSD1)is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3,thereby mediating gene repression[1]....
[会议论文] 作者：Hui YANG,Yi-Chao ZHENG,Bin HE,Hong-Min LIU,Feng-Wu Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Small interfering RNAs(siRNAs)have been widely used to identify gene function and hold great potential in providing a new class of drug for disease treatment....
Prokaryotic expression of human histone lysine specific demethylase 2 and its biological significanc
[会议论文] 作者：Bai-ling Jiang,Yi-Chao Zheng,Jin-lian Ma,Hong-Min Liu,Wen Zhao,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
LSD1(also known as KDM1A)is the first identified histone lysine demethylase.It converts mono-or di-methylated histone H3(H3K4me1/me2)to unmodified H3[1]....
[会议论文] 作者：Zhou Wen-juan,Shi Xiao-jing,Ji Ya-ge,Yi-Chao Zheng,Hong-Min Liu,Zhao Wen,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
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[会议论文] 作者：Li-Juan Zhao,Li-Jie Zhao,Jin-Lian Ma,Yi-Chao Zheng,Wen Zhao,Hong-Min Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
LSD1(Histone lysine specific demethylase 1)was the first identified histone demethylase,which can demethylate mono-,di-methylation of H3K4 and H3K9 as well as other non-histone substrates....
[会议论文] 作者：Wen-lei LV,Yi-chao ZHENG,Rui-min XU,Jin-lian MA,Ke YANG,Wen ZHAO,Hong-min LIU,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
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The mechanism of Histone lysine-specific demethylase 1 regulating TGF-β1 expression in gastric epith
[会议论文] 作者：Jin-Feng Li,Zhi-Ru Wang,Jin-Lian Ma,Yi-Chao Zheng,Chun-yang Wang,Wen Zhao,Hong-Min Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Lysine specific demethylase 1(LSD1),the first identified histone lysine demethylase by Yang Shi group in 2004[1],specifically catalyzes demethylation of mono-and di-methylated lysine 4 and lysine 9 of...
Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro
[会议论文] 作者：Yi-chao ZHENG,Wen-lei LV,Jin-lian MA,Ang YANG,Jin-feng LI,Zhi-ru WANG,Wen ZHAO,Hong-min LIU,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
Bio-activity of novel Histone Lysine specific demethylase1inhibitorin human gastric cancer cell line
[会议论文] 作者：Jin-lian MA,Yi-chao ZHENG,Wen ZHAO,Wen-Lei LV,Ang YANG,Zhi-Ru WANG,Jin-Feng LI,Hong-min LIU,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
Bio-activity of novel Histone Lysine specific demethylase1inhibitorin human gastric cancer cell line
[会议论文] 作者：Jin-lian MA,Yi-chao ZHENG,Wen ZHAO,Wen-Lei LV,Ang YANG,Zhi-Ru WANG,Jin-Feng LI,Hong-min LIU,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aims: Histone epigenetic modifications including acetylation, methylation,phosphorylation and ubiquitination play important roles in structural changes of chromatin.Lysine specific demethylase1(LSD1)...
Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro
[会议论文] 作者：Yi-chao ZHENG,Wen-lei LV,Jin-lian MA,Ang YANG,Jin-feng LI,Zhi-ru WANG,Wen ZHAO,Hong-min LIU,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well as gene activation and repression.Lysinespecific demythelase 1 (LSD1), the first...
[会议论文] 作者：Xi-xin Wang,Jun Yuan,Shuai Wang,Long-zhen Wang,Gui-xing Zhang,Yi-chao Zheng,Wen Zhao,Hong-Min Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Inteins are internal protein elements that self-excise from their host protein and catalyze ligation of the exteins with a peptide bond....
Study on the modulation of gastric cancer cell growth,invasion and migration by novel potent LSD1 in
[会议论文] 作者：Yi-Chao Zheng,Jin-Lian Ma,Wen-Lei Lv,Jin-Feng Li,Zhi-Ru Wang,Hui-Zi Ge,Wen Zhao,Hong-Min Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
The post-translational modifications of histone,e.g.methylation and demythalation,regulate chromatin structure as well as gene activation and repression....
Effects of a novel histone lysine specific demethylase1 inhibitor on EMT in human gastric cancer cel
[会议论文] 作者：Jin-lian Ma,Yi-chao Zheng,Jin-feng Li,Zhi-ru Wang,Long-zhen Wang,Wen-lei Lv,Ming-hao Li,Wen Zhao,Hong-Min,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Aim: Epithelial-mesenchymal transition(EMT)plays crucial roles during embryonic development and carcinoma progression,through downregulating epithelial markers and disassembling cell-cell adhesions,re...
[会议论文] 作者：Yi-Chao Zheng,Jin-Lian Ma,Jin-Feng Li,Zhi-Ru Wang,Long-Zhen Wang,Li-Jie Zhao,Li-Juan Zhao,Qian-Na Zhan,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di-methylated histon3 lysine 4(H3K41/2)and histone 3 lysine 9(H3K9me1/2)when it is...
[会议论文] 作者：Jin-Lian Ma,Yi-Chao Zheng,Jin-Feng Li,Zhi-Ru Wang,Long-Zhen Wang,Qian-Na Zhan,Li-Juan Zhao,Li-Jie Zhao,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Epithelial-mesenchymal transition(EMT)is a crucial process in embryonic development and carcinoma progression.Downregulating epithelial markers and disassembling cell-cell adhesions in this transition...
[会议论文] 作者：Ya-Ge Ji,Yi-Chao Zheng,Xiao-Jing Shi,Wen-juan Zhou,Xue-Peng Geng,Tian-Tian Han,Jing-Jing Hong,Ting Feng,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The p53 tumor suppressor protein plays a key role in regulation of several important cellular processes,including cell cycle,apoptosis,DNA repair and angiogenesis....
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