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[会议论文] 作者：Qi-Kun Yin,Ou-Tian Miao,Zhi-Shu Huang,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
The human Bloom syndrome gene(BLM)encodes a RecQ 3-5 DNA helicase,which is important in genomic stability by suppressing sister chromatid exchanges(SCE)duri...
[会议论文] 作者：Yu-Ting Lu,Yong-Rao,Zhi-Shu Huang,Lian-Quan Gu,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep...
Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者：Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源：2013中国药学大会暨第十三届中国药师周 年份：2013
...
Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者：Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源：2013中国药学大会暨第十三届中国药师周 年份：2013
...
Quinazoline Derivative SYSUQ-03: A Specific Ligand that Regulate the Cap-Independent Translation Ini
[会议论文] 作者：Yue Wu,Xiao-qin Wang,Tiao-miao Ou,Zhi-shu Huang,
来源：第八届全国化学生物学学术会议 年份：2013
Vascular endothelial growth factor (VEGF), a pluripotent cytokine and angiogenic growth factor, which is over-expressed in many types of cancer, plays crucial roles in embryonic development and tumour...
BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者：Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：第13届亚洲化学大会(13th Asian Chemical Congress) 年份：2009
...
Bouchardatine and its analogues inhibition of adipogenesislipogenesis through activating AMPK pathwa
[会议论文] 作者：Yong Rao,Hong Liu,Lin Gao,Hong Yu,Zhi-Shu Huang,
来源：中国化学会第十届全国天然有机化学学术会议 年份：2014
Bouchardatine is a naturally occurring alkaloid isolated from Bouchardatia neurococca (Rutaecae).In this study, we explored the mechanism by which bouchardatine...
BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者：Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：第13届亚洲化学大会(13th Asian Chemical Congress) 年份：2009
...
Specific Recognition of Quindoline Derivatives on Promoter G-Quadruplex and the Biological Relevance
[会议论文] 作者：Tian-miao Ou,Yue Wu,Jia-heng Tan,Lian-quan Gu,Zhi-shu Huang,
来源：第八届全国化学生物学学术会议 年份：2013
G-quadruplexes are unique secondary structure exist in various non-coding region of human genome and exhibit important biological roles in the regulation of gene replication, transcription, and transl...
Exploration of the Mechanism for Isoliquiritigenin Derivatives Inhibiting Aβ(1-42)Self-aggregation A
[会议论文] 作者：Yi-Ping Chen,Ling Wang,Jun Xu,Zhi-Shu Huang,Lian-Quan Gu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
A series of new isoliquiritigenin(ISL)derivatives were synthesized and evaluated as inhibitors for amyloid-beta(Aβ)aggregation.It was found that all these synthetic compounds inhibited Aβ(1-42)self-ag...
Synthesis and Evaluation of Acridine Derivatives as a New Class of Selectively Ligands to Binding c-
[会议论文] 作者：Sheng-rong Liao,Si-tian Zhuo,Peng-hui Li,Lian-quan Gu,Zhi-shu Huang,
来源：第七届全国化学生物学学术会议 年份：2011
The nuclease hypersensitivity element (NHE) Ⅲ1 upstream of the P1 promoter that controls 85-90% of the human c-myc promoter transcriptional activation has been attracted considerable research over the...
[会议论文] 作者：Chan Shan,Jing Lin,Jin-Qiang Hou,Jia-Heng Tan,Tian-Miao Ou,Zhi-Shu Huang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
c-MYC is a classical G-quadruplex-relating gene that is considered as an effective target for anticancer therapy [1].The transcriptional factor NM23-H2 coul...
[会议论文] 作者：Jun Qiu,Siqi Chen,Nannan Xiao,Jiaheng Tan,Tianmiao Ou,Lianquan Gu,Zhi-Shu Huang,Ding Li,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
hnRNP K,a member of the family of heterogeneous ribonucleoproteins,is known to exert various functional roles in the nucleus,cytoplasm,and mitochondria to affect various cellular processes including c...
Small-Molecule-Induced Transcription Repression through Interfering with NM23-H2 Binding to G-quadru
[会议论文] 作者：Jing Lin,Chan Shan,Tian-Miao Ou,Jin-Qiang Hou,Shuo-bin Chen,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
NM23-H2 protein is identified as a transcriptional factor of the important oncogene c-myc,that can bind specifically to defined DNA sequences to promote gene transcription.However,due to its role in t...
[会议论文] 作者：Jin-Wu Yan,Wen-Jie Ye,Yan-ping Li,Jin-Qiang Hou,Jian-Hui Li,Jia-heng Tan,Tian-Miao Ou,Lian-Quan Gu,Zhi-Shu Huang,
来源：第七届全国化学生物学学术会议 年份：2011
...
Discovery of Novel Anti-tumour Agents for Specific Recognizing the G-quadruplex in 5-Untranslated Re
[会议论文] 作者：Yue Wu,Xiao-Qin Wang,Guo-Tao Kuang,Qi Zhang,Giulia Biffi,Shu-Ling Lin,Hui-Yun Liu,Jia-Heng Tan,Zhi-Shu Huang,
来源：第九届全国核糖核酸(RNA)学术讨论会 年份：2016
Angiogenesis is important in tumorigenesis and tumor progress.Human vascular endothelial growth factor(hVEGF)is an angiogenic growth factor that plays a cru...
[会议论文] 作者：Ying Chun Chen,Ji Ming Ye,Zhi-Shu Huang,Xiao Yi Zeng,Yan He,Hong Liu,Bin Wang,Han Zhou,Jian-Wen Chen,,
来源：第八届全国化学生物学学术会议 年份：2013
Obesity results from expansion of adipose tissue which due to an increase in adipocyte number (adipogenesis) and adipocyte size (lipogenesis).Thus inhibition of...
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