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[会议论文] 作者:Qi-Kun Yin,Ou-Tian Miao,Zhi-Shu Huang,
来源:中国化学会第十届全国化学生物学学术会议 年份:2017
The human Bloom syndrome gene(BLM)encodes a RecQ 3-5 DNA helicase,which is important in genomic stability by suppressing sister chromatid exchanges(SCE)duri...
[会议论文] 作者:Yu-Ting Lu,Yong-Rao,Zhi-Shu Huang,Lian-Quan Gu,
来源:中国化学会第十届全国化学生物学学术会议 年份:2017
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep...
Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者:Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源:2013中国药学大会暨第十三届中国药师周 年份:2013
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Design,Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Al
[会议论文] 作者:Yi-Ping Chen,Zhi-Shu Huang,Jun Xu,Lian-Quan Gu,
来源:2013中国药学大会暨第十三届中国药师周 年份:2013
...
Quinazoline Derivative SYSUQ-03: A Specific Ligand that Regulate the Cap-Independent Translation Ini
[会议论文] 作者:Yue Wu,Xiao-qin Wang,Tiao-miao Ou,Zhi-shu Huang,
来源:第八届全国化学生物学学术会议 年份:2013
Vascular endothelial growth factor (VEGF), a pluripotent cytokine and angiogenic growth factor, which is over-expressed in many types of cancer, plays crucial roles in embryonic development and tumour...
BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者:Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源:第13届亚洲化学大会(13th Asian Chemical Congress) 年份:2009
...
Bouchardatine and its analogues inhibition of adipogenesislipogenesis through activating AMPK pathwa
[会议论文] 作者:Yong Rao,Hong Liu,Lin Gao,Hong Yu,Zhi-Shu Huang,
来源:中国化学会第十届全国天然有机化学学术会议 年份:2014
Bouchardatine is a naturally occurring alkaloid isolated from Bouchardatia neurococca (Rutaecae).In this study, we explored the mechanism by which bouchardatine...
BM-IL12:G-quadruplex as targets in anticancer drug design:the design and evaluation of quindoline de
[会议论文] 作者:Tian-Miao Ou,Yu-Jing Lu,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源:第13届亚洲化学大会(13th Asian Chemical Congress) 年份:2009
...
Specific Recognition of Quindoline Derivatives on Promoter G-Quadruplex and the Biological Relevance
[会议论文] 作者:Tian-miao Ou,Yue Wu,Jia-heng Tan,Lian-quan Gu,Zhi-shu Huang,
来源:第八届全国化学生物学学术会议 年份:2013
G-quadruplexes are unique secondary structure exist in various non-coding region of human genome and exhibit important biological roles in the regulation of gene replication, transcription, and transl...
Exploration of the Mechanism for Isoliquiritigenin Derivatives Inhibiting Aβ(1-42)Self-aggregation A
[会议论文] 作者:Yi-Ping Chen,Ling Wang,Jun Xu,Zhi-Shu Huang,Lian-Quan Gu,
来源:全国药物化学学术会议暨第四届中英药物化学学术会议 年份:2013
A series of new isoliquiritigenin(ISL)derivatives were synthesized and evaluated as inhibitors for amyloid-beta(Aβ)aggregation.It was found that all these synthetic compounds inhibited Aβ(1-42)self-ag...
Synthesis and Evaluation of Acridine Derivatives as a New Class of Selectively Ligands to Binding c-
[会议论文] 作者:Sheng-rong Liao,Si-tian Zhuo,Peng-hui Li,Lian-quan Gu,Zhi-shu Huang,
来源:第七届全国化学生物学学术会议 年份:2011
The nuclease hypersensitivity element (NHE) Ⅲ1 upstream of the P1 promoter that controls 85-90% of the human c-myc promoter transcriptional activation has been attracted considerable research over the...
[会议论文] 作者:Chan Shan,Jing Lin,Jin-Qiang Hou,Jia-Heng Tan,Tian-Miao Ou,Zhi-Shu Huang,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
c-MYC is a classical G-quadruplex-relating gene that is considered as an effective target for anticancer therapy [1].The transcriptional factor NM23-H2 coul...
[会议论文] 作者:Jun Qiu,Siqi Chen,Nannan Xiao,Jiaheng Tan,Tianmiao Ou,Lianquan Gu,Zhi-Shu Huang,Ding Li,
来源:第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份:2012
hnRNP K,a member of the family of heterogeneous ribonucleoproteins,is known to exert various functional roles in the nucleus,cytoplasm,and mitochondria to affect various cellular processes including c...
Small-Molecule-Induced Transcription Repression through Interfering with NM23-H2 Binding to G-quadru
[会议论文] 作者:Jing Lin,Chan Shan,Tian-Miao Ou,Jin-Qiang Hou,Shuo-bin Chen,Jia-Heng Tan,Lian-Quan Gu,Zhi-Shu Huang,
来源:全国药物化学学术会议暨第四届中英药物化学学术会议 年份:2013
NM23-H2 protein is identified as a transcriptional factor of the important oncogene c-myc,that can bind specifically to defined DNA sequences to promote gene transcription.However,due to its role in t...
[会议论文] 作者:Jin-Wu Yan,Wen-Jie Ye,Yan-ping Li,Jin-Qiang Hou,Jian-Hui Li,Jia-heng Tan,Tian-Miao Ou,Lian-Quan Gu,Zhi-Shu Huang,
来源:第七届全国化学生物学学术会议 年份:2011
...
Discovery of Novel Anti-tumour Agents for Specific Recognizing the G-quadruplex in 5-Untranslated Re
[会议论文] 作者:Yue Wu,Xiao-Qin Wang,Guo-Tao Kuang,Qi Zhang,Giulia Biffi,Shu-Ling Lin,Hui-Yun Liu,Jia-Heng Tan,Zhi-Shu Huang,
来源:第九届全国核糖核酸(RNA)学术讨论会 年份:2016
Angiogenesis is important in tumorigenesis and tumor progress.Human vascular endothelial growth factor(hVEGF)is an angiogenic growth factor that plays a cru...
[会议论文] 作者:Ying Chun Chen,Ji Ming Ye,Zhi-Shu Huang,Xiao Yi Zeng,Yan He,Hong Liu,Bin Wang,Han Zhou,Jian-Wen Chen,,
来源:第八届全国化学生物学学术会议 年份:2013
Obesity results from expansion of adipose tissue which due to an increase in adipocyte number (adipogenesis) and adipocyte size (lipogenesis).Thus inhibition of...
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