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Novel PPARγ binding activity modulator discovery based on the PPARγ-Gal4 chimera receptor and its mu
[会议论文] 作者：Yi HUAN,Jun PENG,Zhu-fang SHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
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Novel PPARγ binding activity modulator discovery based on the PPARγ-Gal4 chimera receptor and its mu
[会议论文] 作者：Yi HUAN,Jun PENG,Zhu-fang SHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aim: To discover novel PPARy modulator, PPARy-Gal4 chimera receptor and its mutant derivatives were applied to evaluate the binding activity of ligands and their molecular basis of interaction.Methods...
[会议论文] 作者：Min-zhi LIU,Wei WANG,Jun PENG,Zhu-fang SHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
Pioglitazone exacerbates the hepatic steatosis and suppresses serum cholesterol clearance in two ani
[会议论文] 作者：Jun PENG,Yi HUAN,Min-zhi LIU,Zhu-fang Shen,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
JTN, an α-glucosidase inhibitor from Bombyx mori excreta exerts hypoglycemic effects and improves be
[会议论文] 作者：Quan LIU,Shuai-Nan LIU,Su-Juan SUN,Zhu-Fang SHEN,
来源：第二届世界天然药物和传统药物药理学学术会议 年份：2012
AIM To evaluate the impact of JTN on beta cell function in mice with impaired glucose tolerance (IGT).METHODS Two animal models with IGT were chosen to evaluate the effect of JTN on beta cell function...
Pioglitazone exacerbates the hepatic steatosis and suppresses serum cholesterol clearance in two ani
[会议论文] 作者：Jun PENG,Yi HUAN,Min-zhi LIU,Zhu-fang Shen,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aim: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) frequently coexist as they share the pathogenic abnormalities of excess adiposity and insulin resistance.The insulin s...
IMM-YR, a Novel Compound Improves Insulin Resistance and Dyslipidemia in Dietary-induced Obese C57BL
[会议论文] 作者：Chun-ming Jia,Shuai-nan Liu,Yi Huan,Jun Peng,Zhu-fang Shen,
来源：The 6th China-Russia International Conference on Medicine(第六 年份：2014
...
IMM-YR, a Novel Compound Improves Insulin Resistance and Dyslipidemia in Dietary-induced Obese C57BL
[会议论文] 作者：Chun-ming Jia,Shuai-nan Liu,Yi Huan,Jun Peng,Zhu-fang Shen,
来源：The 6th China-Russia International Conference on Medicine(第六 年份：2014
Aim: To investigate the effects of IMM-YR on insulin resistance and dyslipidemia in dietary-induced obese (DIO) C57BL/6J mice.Methods: Male C57BL/6J mice were fed with high fat diet for 4 months.Obese...
,Pioglitazone can ameliorate insulin resistance in low-dose streptozotocin and high sucrose-fat diet
[期刊论文] 作者：Shi-ying DING,Zhu-fang SHEN,Yue-teng CHEN,Su-juan SUN,Quan Liu,Ming-zhi XIE,
来源：中国药理学报（英文版） 年份：2005
Aim: To investigate the effect of the peroxisome proliferator-activator receptor (PPAR)-γ agonist, pioglitazone, on insulin resistance in low-dose streptozotoc...
[期刊论文] 作者：Ning ZHANG,Yi HUAN,Hui HUANG,Guang-ming SONG,Su-juan SUN,Zhu-fang SHEN,
来源：中国药理学报（英文版） 年份：2010
...
Design, synthesis and metabolic regulation effect of farnesoid X receptor (FXR) antagonistic benzoxe
[期刊论文] 作者：Guo-Ning Zhang,Yi Huan,Xing Wang,Su-Juan Sun,Zhu-Fang Shen,Wei-Shuo Fang,,
来源：Chinese Chemical Letters 年份：2017
A series of benzoxepin-5-ones were designed and synthesized by the cyclization of chalcones which were previously found as FXR antagonists. The cellular FXR ant...
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