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,CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeost
[期刊论文] 作者：Ping Wang,Zunpeng Liu,Xiaoqian Zhang,Jingyi Li,Liang Sun,Zhenyu Ju,Jian Li,Piu Chan,Guang-Hui Liu,Weiqi,
来源：蛋白质与细胞 年份：2018
Vascular cell functionality is critical to blood vessel homeostasis.Constitutive NF-κB activation in vascular cells results in chronic vascular inflammation,le...
[期刊论文] 作者：Lingling Geng,Zunpeng Liu,Si Wang,Shuhui Sun,Shuai Ma,Xiaoqian Liu,Piu Chan,Liang Sun,Moshi Song,Weiqi,
来源：蛋白质与细胞 年份：2019
Dear Editor,Aging is the leading risk factor for many chronic diseases,accounting for almost 60％ of all deaths worldwide.How to achieve healthy aging,alleviate a...
[期刊论文] 作者：Fang Cheng,Si Wang,Moshi Song,Zunpeng Liu,Ping Liu,Lei Wang,Yanjiang Wang,Qian Zhao,Kaowen Yan,Piu Chan,
来源：蛋白质与细胞 年份：2019
Dear Editor,Safeguarding cellular redox homeostasis is crucial for maintaining organism health and preventing diseases.Oxidative stress,often characterized by d...
[期刊论文] 作者：Zunpeng Liu,Weiqi Zhang,Wei Li,Zeming Wu,Wei Wang,Ruotong Ren,Yao Su,Peichang Wang,Liang Sun,Zhenyu Ju,Piu Chan,
来源：蛋白质与细胞 年份：2019
Aging increases the risk of various diseases.The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases.In t...
[期刊论文] 作者：Zeming Wu,Weiqi Zhang,Moshi Song,Wei Wang,Gang Wei,Wei Li,Jinghui Lei,Yu Huang,Yanmei Sang,Piu Chan,Chang,
来源：蛋白质与细胞 年份：2018
Hutchinson-Gilford progeria syndrome (HGPS) and Wemer syndrome (WS) are two of the best characterized human progeroid syndromes.HGPS is caused by a point mutati...
[期刊论文] 作者：Zheng,Pengze Yan,Moshi Song,Si Wang,Liang Sun,Zunpeng Liu,Shuai Ma,Juan Carlos Izpisua Belmonte,Piu Chan,
来源：国家科学评论（英文版） 年份：2021
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the...
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocard
[期刊论文] 作者：Chu,Zunpeng Liu,Liang Sun,Yun Ji,Concepcion Rodriguez Esteban,Yan Yao,Juan Carlos Izpisua Belmonte,Piu Chan,
来源：蛋白质与细胞 年份：2021
Dear Editor,rnMyocardial infarction(MI)is the irreversible cardiomyocyte death resulting from prolonged oxygen deprivation due to obstructed blood supply(ischem...
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
[期刊论文] 作者：Wang,Kaowen Yan,Liang Sun,Tomoaki Hishida,Yanning Cai,Juan Carlos Izpisua Belmonte,Pedro Guillen,Piu Chan,
来源：细胞研究（英文版） 年份：2021
Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadia...
[期刊论文] 作者：Ruotong Ren,Weiqi Zhang,Moshi Song,Huifang Hu,Feifei Liu,Guoqiang Sun,Shuhui Sun,Zunpeng Liu,Yang Yu,Piu Chan,
来源：蛋白质与细胞 年份：2021
Dear Editor,rnThe retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment i......
[期刊论文] 作者：Jiaming Li,Jie Ren,Shuhui Sun,Shuai Ma,Weiqi Zhang,Yang Yu,Yusheng Cai,Kaowen Yan,Wei Li,Baoyang Hu,Piu Chan,
来源：蛋白质与细胞 年份：2021
The hippocampus plays a crucial role in leaming and mem-ory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hip-po......
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