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[期刊论文] 作者：Zhaohui Zhong,Simon Sretenovic,Qiurong Ren,Lijia Yang,Yu Bao,Caiyan Qi,Mingzhu Yuan,Yao He,Shishi Liu,
来源：分子植物（英文版） 年份：2019
Two recently engineered SpCas9 variants,namely xCas9 and Cas9-NG,show promising potential in improving targeting specificity and broadening the targeting range....
[期刊论文] 作者：Fang Wang,Weiqi Zhang,Qiaoyan Yang,Yu Kang,Yanling Fan,Jingkuan Wei,Zunpeng Liu,Shaoxing Dai,Hao Li,Zifan,
来源：蛋白质与细胞 年份：2020
Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premat...
[期刊论文] 作者：Yiyuan Zhang,Shanshan Yang,Zunpeng Liu,Zeming Wu,Sheng Zhang,Qiaoran Wang,Aihua Zheng,Shuguang Duo,Yang Yu,
来源：细胞研究（英文版） 年份：2021
Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Diseas...
[期刊论文] 作者：Xiaojuan He,Ruotong Ren,Weiqi Zhang,Moshi Song,Huifang Hu,Feifei Liu,Guoqiang Sun,Shuhui Sun,Zunpeng Liu,Yang Yu,
来源：蛋白质与细胞 年份：2021
Dear Editor,rnThe retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment i......
SKLB1206, a Novel Orally Available Multikinase Inhibitor Targeting EGFR Activating and T790M Mutants
[会议论文] 作者：Yong Xu,Shan Feng,Shidong Luo,Renlin Zheng,Jiao Yang,Lijiao Wang,Lei Zhong,Han-Yu Yang,Bing-Lin Wang,Yang Yu,
来源：四川大学博士生学术论坛2015年年会 年份：2015
Anti-epidermal growth factor receptor(EGFR)treatment has been successfully applied in clinical cancer therapy.However,the clinical efficacy of first-generation reversible EGFR inhibitors,such as gefit...
[期刊论文] 作者：Guoqiang Li,Yang Yu,Yong Fan,Congru Li,Xiaocui Xu,Jialei Duan,Rong Li,Xiangjin Kang,Xin Ma,Xuepeng Chen,
来源：Journal of Genetics and Genomics 年份：2017
Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming...
[期刊论文] 作者：Hui Zhang,Jiaming Li,Jie Ren,Shuhui Sun,Shuai Ma,Weiqi Zhang,Yang Yu,Yusheng Cai,Kaowen Yan,Wei Li,Baoyang,
来源：蛋白质与细胞 年份：2021
The hippocampus plays a crucial role in leaming and mem-ory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hip-po......
Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice
[期刊论文] 作者：Jiachang Wang,Yulong Ren,Xi Liu,Sheng Luo,Xiao Zhang,Xin Liu,Qibing Lin,Shanshan Zhu,Hua Wan,Yang Yang,Yu,
来源：分子植物（英文版） 年份：2021
Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been reco...
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