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Clinical Pharmacology Research in ChinaPast and Present--A story of an innovative target antitumor d
[会议论文] 作者：Pei Hu,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Outline· Past-There was no guidance in those early years -Mainly conducted BE trials of generic drugs -Generic PK trials of imported drugs requested by SFDA ·...
Alternative Methods for CYP2D6 Phenotyping: Comparison of Dextromethorphan Metabolic Ratios from AUC
[会议论文] 作者：Rui Chen,Pei Hu,
来源：第十四届全国生化与分子药理学学术会议 年份：2015
...
[会议论文] 作者：Dongyang Liu,Pei Hu,
来源：第五届定量药理学与新药评价国际会议 年份：2015
...
Alternative Methods for CYP2D6 Phenotyping: Comparison of Dextromethorphan Metabolic Ratios from AUC
[会议论文] 作者：Rui Chen,Pei Hu,
来源：第十四届全国生化与分子药理学学术会议 年份：2015
Purpose:Cytochrome P450 2D6 (CYP2D6) is one of the most widely investigated polymor phic enzymes owing to its wide inter-individual and inter-ethnic variations.It is convenient to test genotypes clini...
Evaluation of the phenotyping methods of CYP2D6 using aphysiologically-based pharmacokinetic model o
[会议论文] 作者：Rui Chen,Pei Hu,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background and Aim: Hepatic enzyme CYP2D6 plays an important role in metabolizing many drugs and its genetic polymorphism results in significant individual therapeutic difference.Estimating the phenot...
[期刊论文] 作者：Li MA,Zu-ncng LU,Pei HU,Chang-,
来源：华中科技大学学报：医学英德文版 年份：2015
The neuroprotective effects of escitalopram oxalate in rats with chronic hypoperfusion and the possible mechanism were explored. Chronic hypoperfusion(2-VO) mod...
[期刊论文] 作者：Li MA,Zu-neng LU,Pei HU,Chang-,
来源：华中科技大学学报（医学英德文版） 年份：2015
...
Predictions about probabilities of adverse events and appropriate dose of roflumilast for Chinese CO
[会议论文] 作者：Xinge Cui,Xin Zheng,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
...
Population pharmacokinetic pharmacodynamics model for PEGylated human growth hormone in healthy subj
[会议论文] 作者：Xin Zheng,Xia Chen,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
...
Application of population pharmacokinetic modeling in clinical development of a novel PPI CPRCX: com
[会议论文] 作者：Xuemei Liu,Hongyun Wang,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
...
Application of population pharmacokinetic modeling in clinical development of a novel PPI CPRCX: com
[会议论文] 作者：Xuemei Liu,Hongyun Wang,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
CPRCX is a novel investigated proton pump inhibitor, which shows dramatic success in the management of acid-related disorders.Now this drug is being developed in Phase Ⅱ study in China.In this paper f...
Population pharmacokinetic pharmacodynamics model for PEGylated human growth hormone in healthy subj
[会议论文] 作者：Xin Zheng,Xia Chen,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background: Growth hormone deficiency (GHD) in paediatric and adult patients so currently necessitates long-term treatment and persistence with a daily s.c injection regimen.Taking the low compliance...
Predictions about probabilities of adverse events and appropriate dose of roflumilast for Chinese CO
[会议论文] 作者：Xinge Cui,Xin Zheng,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Backgrounds: Roflumilast is an oral inhibitor of phosphodiesterase 4(PDE4), which is mainly metabolized by CYP3A4 and CYP1A2.The main metabolite of it is roflumilast N-oxide, which contributes to the...
Effect of Target-Mediated Drug Disposition on CPRC3 Pharmacokinetics and Pharmacodynamics in Healthy
[会议论文] 作者：Zhenlei Wang,Qian Zhao,Dongyang Liu,Yupeng Ren,Ji Jiang,Pei Hu,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background: The prevalence of diabetes mellitus (DM) dramatically increased over the past decades.Dipeptidyl peptidase Ⅳ (DPP-4) inhibitors are a relatively new group of anti-diabetic agents.CPRC3 is...
[会议论文] 作者：Jun Shi,Sheng Feng,Meret Martin-Facklam,Cornelia Weber,Richard Peck,Neil Parrott,Pei Hu,Tomohisa Saito,
来源：第五届定量药理学与新药评价国际会议 年份：2015
...
[会议论文] 作者：Sheng Feng,Jun Shi,Neil Parrott,Pei Hu,Cornelia Weber,Meret Martin-Facklam,Tomohisa Saito,Richard Peck,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background and objectives: Bitopertin (RG1678, RO4917838) is a glycine reuptake inhibitor that is postulated to improve NMDA receptor hypofunction by increasing the synaptic concentration of glycine,...
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