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[期刊论文] 作者：Fei-fei Xu,Hui-min Sun,Run-ping Fang,Lu Zhang,Hui Shi,Xue Wang,Xue-li Fu,Xian-meng Li,Xu-he Shi,Yue Wu,
来源：中国药理学报（英文版） 年份：2022
Programmed death ligand-1(PD-L1)/PD-1 checkpoint extensively serves as a central mediator of immunosuppression.A tumor-promoting role for abundant PD-L1 in several cancers is revealed.However,the importance of PD-L1 and how the PD-L1 expres......
[期刊论文] 作者：郭栋,李超超,闫伟,郝玉娇,徐艺,王玉琼,周英超,俄文娟,张同庆,高兴邦,谭啸川,FANG Jing-hua,
来源：中南大学学报（英文版） 年份：2022
由于电动汽车电池技术限制及相关配套设施不完善等原因,电动汽车在行驶途中仍存在较大的抛锚风险,由此产生的驾驶员出行焦虑问题极大地限制了电动汽车出行品质的提升,成为当前电动汽车推广和发展亟需解决的难题.本文提出一种考虑电动汽车电量补给的出行路径规划......
[期刊论文] 作者：Kai-Qi Wang,Ya-Hui Yu,Xin-Lei Jia,Si-Da Zhou,Fang Zhang,Xin Zhao,Ming-Yue Zhai,Yi Gong,Jie-Yang Lu,Yuyi,
来源：植物学报（英文版） 年份：2022
Photoperiod/temperature-sensitive genic male ster-ility (P/TGMS) is widely applied for improving crop production. Previous investigations using the rever-sible male sterile (rvms) mutant showed that slow development is a general mechanism f......
[期刊论文] 作者：Xiang-lei Zhang,Bing-qian Li,Hong-lin Li,Ye-chun Xu,Eric H.Xu,Hua-liang Jiang,Li-li Zhu,Lei-ke Zhang,Fang,
来源：中国药理学报（英文版） 年份：2022
The COVID-19,caused by SARS-CoV-2,is threatening public health,and there is no effective treatment.In this study,we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors,which simu......
DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibi
[期刊论文] 作者：Wei Nie,Min-juan Hu,Qin Zhang,Jun Lu,Fang-fei Qian,Le-le Zhang,Fang Hu,Chang-hui Li,Shu-hui Cao,Jing-wen,
来源：中国药理学报（英文版） 年份：2022
Long noncoding RNAs(IncRNAs)are involved in a variety of cancers,but the role of LncRNA DUBR in lung adenocarcinoma(LUAD),the most prevalent form of lung cancer,remains unclear.In this study we investigated the expression of DUBR in LUAD to......
[期刊论文] 作者：XUE Yuan,YANG Jia Hui,GAO Ming Yue,ZHAO Wei,LI Chun Mei,XIE XiangHong,ZHANG Wei Hong,ZHANG Hua Bing,FANG,
来源：生物医学与环境科学（英文版） 年份：2022
Mitochondria are important intracellular organelles that carry out oxidative phosphorylation, synthesize ATP, and provide energy for cell activities....
[期刊论文] 作者：Tan,Youjin Zhang,Haihong Zhou,Xianqing Liu,Ling Liu,Yiding Jiangfang,Yufei Li,Zhenhuan Liu,Chuanying Fang,
来源：分子植物（英文版） 年份：2022
Volatile organic compounds play essential roles in plant environment interactions as well as determining the fragrance of plants.Although gas chromatography-mass spectrometry-based untargeted metabolo-mics is commonly used to assess plant v......
[期刊论文] 作者：Ye,Lei Tong,Peng Wang,Yang Wang,Hailu Wang,Haonan Ge,Zhen Wang,Yue Gu,Kun Zhang,Yiye Yu,Meng Peng,Fang,
来源：光：科学与应用（英文版） 年份：2022
With the increasing demand for multispectral information acquisition, infrared multispectral imaging technology that is inexpensive and can be miniaturized and integrated into other devices has received extensive attention. However, the wid......
Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T c
[期刊论文] 作者：Shanshan Wang,Xiaojie Qi,Yawen Zhang,Zonghua Liu,Jing Luo,Hui Liu,Yongbing Ba,Lianxia Guo,Baojian Wu,Fang,
来源：科学通报（英文版） 年份：2022
The distinct characteristics of γδ T cells determine their vital roles in the formation of local immune responses and contribute to tissue homeostasis.However,the heterogeneity of γδ T cells across tissues remains unclear.By combining t......
KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiat
[期刊论文] 作者：Huo,Yue Ren,Weiqian Li,Le Chang,Dongxu Lu,Yuehong Guo,Yanmin Si,Yufeng Gao,Xiaoshuang Wang,Yanni Ma,Fang,
来源： 年份：2022
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A comprehensive profile of TCF1+progenitor and TCF1?terminally exhausted PD-1+CD8+T cells in head an
[期刊论文] 作者：Dikan Wang,Juan Fang,Shuqiong Wen,Qunxing Li,Jinming Wang,Lisa Yang,Wenxiao Dai,Huanzi Lu,Junyi Guo,Zhongyan,
来源：国际口腔科学杂志（英文版） 年份：2022
The heterogeneity of exhausted T cells (Tex) is a critical determinant of immune checkpoint blockade therapy efficacy. However, few studies have explored exhausted T cell subpopulations in human cancers. In the present study, we examined sa......
Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomi
[期刊论文] 作者：Shi,Yifan Zhang,Guixian Liang,Zhixin Kang,Baofeng Huang,Dongyuan Ma,Lu Wang,Jianwei Jiao,Xiangdong Fang,
来源：细胞研究（英文版） 年份：2022
Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor (HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological mal......
Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to h
[期刊论文] 作者：Lidong Dong,Qun Cheng,Chao Fang,Lingping Kong,Hui Yang,Zhihong Hou,Yongli Li,Haiyang Nan,Yuhang Zhang,
来源：分子植物（英文版） 年份：2022
Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combini......
Prevalence of Acne Inversa (Hidradenitis Suppurativa) in China: A Nationwide Cross-Sectional Epidemi
[期刊论文] 作者：Kang Xiao-Jing,Jiang Xian,Jin Hong-Zhong,Xie Hong-Fu,Sun Qing,Li Hang,Li Shan-Shan,Yuan Chen,He Li,Fang,
来源：国际皮肤性病学杂志（英文） 年份：2022
Objective::This study was performed to estimate the prevalence of hidradenitis suppurativa (HS) in China and describe the demographic and clinical features of HS in the Chinese population.Methods::This multicenter clinic-based cross-section......
[期刊论文] 作者：JiJie Ma,YiTeng Zhang,LiangHai Xie,YuXian Wang,JianSen He,Bin Liu,WenJing Wang,Bin Su,JiaWei Li,Xu Tan,Fang,
来源：地球与行星物理（英文版） 年份：2022
The Mars Ion and Neutral Particle Analyzer (MINPA) is one of the three scientific instruments onboard the Tianwen-1 orbiter to investigate the Martian space environment. During Tianwen-1\'s transfer orbit to Mars, the MINPA was switched on ......
Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and M
[期刊论文] 作者：Tian Ge,LU Jie Li,CHEN Yu Hong,WANG Shuang Yuan,ZHAO Zhi Yun,XU Yu,NING Guang,WANG Wei Qing,BI Yu Fang,
来源：生物医学与环境科学（英文版） 年份：2022
Objective The association between neutrophil-to-lymphocyte ratio (NLR) with subclinicalmacrovascular and microvascular diseases has been less investigated. We sought to examine theassociation between NLR and new-onset subclinical macrovascu......
Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID?19 in a
[期刊论文] 作者：Cheng Fang,Yu?Quan Liu,Le?Yong Yuan,Chun?Yan Peng,Shen?Yi Zhang,Wang Cheng,Hong?Chao Ma,Li?,
来源：军事医学研究（英文版） 年份：2022
Background: Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial D......
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